Neuropsychological profiles and neural correlates in typical and atypical variants of Alzheimer disease: A systematic qualitative review

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dc.catalogadorjlo
dc.contributor.authorFredes-Roa, C.
dc.contributor.authorGutiérrez-Barría, F.
dc.contributor.authorRamírez-Bruna, C.
dc.contributor.authorCigarroa, Igor
dc.contributor.authorMartella, D.
dc.contributor.authorJulio Ramos, Teresa Paz
dc.contributor.authorMéndez Orellana, Carolina Patricia
dc.contributor.authorToloza Ramírez, David Isaias
dc.date.accessioned2026-01-06T19:23:14Z
dc.date.available2026-01-06T19:23:14Z
dc.date.issued2022
dc.description.abstractIntroduction: Neuropsychological symptoms and cortical atrophy patterns show similarities between typical Alzheimer's Disease (AD) and its variants. Thus, correct diagnosis is difficult, leading to errors in the therapeutic process. Indeed, the challenge in cognitive neuroscience focuses on identifying key features of cognitive-linguistic profiles and improving the knowledge of neural correlates for accurate differential diagnosis between the heterogeneous profiles of typical and atypical AD. Aim: This systematic review aims to describe different AD profiles, considering their neuropsychological symptoms and neural correlates. Methods: The present study followed the PRISMA guidelines and included studies from the PubMed, ScienceDirect, Scopus, and Web of Science databases, published between 2011 and 2021. Results: Thirty-one articles were included in this systematic review for critical analysis. Results suggest significant declines in episodic and working memory and executive function. Likewise, in all groups, verbal fluency and visuospatial/visuoconstructive skills declined. However, these symptoms overlap between typical AD, logopenic variant primary progressive aphasia, posterior cortical atrophy, behavioural/dysexecutive or frontal variant AD, and corticobasal syndrome. On the other hand, the neural correlate showed a pattern of atrophy in frontal, temporal, parietal, and occipital areas, even compromising the cuneus and precuneus. Conclusion: Spontaneous language and semantic and phonological verbal fluency could be an important biomarker for differential diagnosis between typical AD and its atypical variants. Likewise, clinical assessment should consider using advanced neuroimaging techniques to establish early associations between brain dysfunction and neuropsychological performance, with particular attention to brain areas such as the cuneus and precuneus.
dc.description.funderANID-Subdirección de Capital Humano/Doctorado
dc.description.funderhealth sciences department of Pontificia Universidad Católica de Chile
dc.description.funderUniversidad Mayor
dc.format.extent26 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.neurop.2022.07.007
dc.identifier.eissn2667-0496
dc.identifier.issn2667-0496
dc.identifier.scopusidSCOPUS_ID:85140335618
dc.identifier.urihttps://doi.org/10.1016/j.neurop.2022.07.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107548
dc.information.autorucDepartamento de Ciencias de la Salud; Julio Ramos, Teresa Paz; S/I; 1028261
dc.information.autorucEscuela de Medicina; Méndez Orellana, Carolina Patricia; 0000-0001-5217-9725; 1015155
dc.information.autorucEscuela de Medicina; Toloza Ramírez, David Isaias; S/I; 1186482
dc.issue.numero3
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaNeurology Perspectives
dc.rightsacceso abierto
dc.rights.licenseCC BY-NC-ND 4.0 Attribution-NonCommercial-NoDerivatives 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by-nc-nd/4.0/
dc.subjectAlzheimer disease
dc.subjectAtypical variants Alzheimer disease
dc.subjectDifferential diagnosis
dc.subjectNeural correlate
dc.subjectNeuropsychological assessment
dc.subject.ddc610
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNeuropsychological profiles and neural correlates in typical and atypical variants of Alzheimer disease: A systematic qualitative review
dc.typereseña
dc.volumen3
sipa.codpersvinculados1028261
sipa.codpersvinculados1015155
sipa.codpersvinculados1186482
sipa.trazabilidadSCOPUS;10-11-2022
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