RESPIRATORY AND CIRCULATORY REFLEXES INDUCED BY NICOTINE INJECTIONS - ROLE OF CAROTID-BODY CHEMORECEPTORS

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dc.contributor.authorZAPATA, P
dc.contributor.authorZUAZO, A
dc.contributor.authorLLADOS, F
dc.date.accessioned2025-01-23T19:45:02Z
dc.date.available2025-01-23T19:45:02Z
dc.date.issued1976
dc.description.abstractI.v. and intracarotid injections of nicotine were delivered to cats anesthetized with pentobarbital. Low doses of nicotine induced reflex hyperventilation and hypertension, mainly due to excitation of carotid body chemoreceptors. The frequency of discharge of carotid nerve chemosensory fibers was increased by nicotine in doses as low as 1 .mu.g/kg when injected i.v. and 50 ng when injected into the carotid artery. Nicotine also activates vagal afferent fibers; some of them produce reflex excitation of the respiratory and vasomotor centers, but others provoke reflex inhibition. High doses of nicotine can act directly upon the medulla provoking acceleration or arrest of ventilation. Nicotine can also induce late changes of b.p. [blood pressure] (delay 5 s or more) which are not mediated by the carotid or vagus nerves.
dc.fuente.origenWOS
dc.identifier.issn0003-9780
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100187
dc.identifier.wosidWOS:A1976BG89300014
dc.issue.numero1
dc.language.isoen
dc.pagina.final139
dc.pagina.inicio128
dc.revistaArchives internationales de pharmacodynamie et de therapie
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRESPIRATORY AND CIRCULATORY REFLEXES INDUCED BY NICOTINE INJECTIONS - ROLE OF CAROTID-BODY CHEMORECEPTORS
dc.typeartículo
dc.volumen219
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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