Growth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy

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dc.catalogadorgjm
dc.contributor.authorDe Toro Navarrete, Valeria Francisca
dc.contributor.authorAlberti, Gigliola
dc.contributor.authorDomínguez, Angélica
dc.contributor.authorCarrasco Negüe, Karina Andrea
dc.contributor.authorFerrer, Pedro
dc.contributor.authorValenzuela, Rodrigo
dc.contributor.authorGarmendia. María Luisa
dc.contributor.authorCasanello Toledo, Paola Cecilia
dc.date.accessioned2024-07-19T14:05:29Z
dc.date.available2024-07-19T14:05:29Z
dc.date.issued2024
dc.description.abstractBackground: Previous studies of maternal docosahexaenoic acid (DHA) supplementation during pregnancy have controversial and contrasting results on the short and long-term effects on early child growth. The impact of this nutritional intervention on the postnatal growth patterns in the offspring of women with pregestational overweight/obesity (PGO) also remains controversial. Objective: To analyze the postnatal growth patterns during the first 4 months of life in the offspring of women with PGO randomly supplemented with 800 mg/day (PGO-800) compared with normative doses of 200 mg/day (PGO-200) of DHA during pregnancy (<15 weeks of gestation until delivery). Methods: This study evaluated the growth patterns during the first 4 months of life of 169 infants of the women that participated in the MIGHT study (NCT02574767). We included the infants of women from the PGO-200 (n = 81) and PGO-800 group (n = 88). The growth patterns (weight, length, and head circumference) and change in z-score (WHO charts) were evaluated. Results: Throughout the first 4 months of life, the infants of the PGO-800 group had lower weight-for-length z-score (coef. −0.65, 95% confidence interval [CI] −1.07, −0.22, p = 0.003) and lower body mass index-for-age z-score (coef. −0.56, 95% CI −0.99, −0.12, p = 0.012) compared with the PGO-200 group adjusted by maternal body mass index, gestational weight gain, gestational age, insulin in cord blood and infant feeding (exclusive breastfed, not breastfed, and partially breastfed). Conclusions: Maternal supplementation with DHA during pregnancy could beneficially limit the offspring's postnatal weight gain during the first 4 months of life.
dc.description.funderPontificia Universidad Católica de Chile
dc.description.funderDIEMUC
dc.description.funderNational Fund for Scientific and Technological Research
dc.description.funderSchool of Medicine
dc.description.funderFONDECYT
dc.description.funderFONDECYT
dc.fechaingreso.objetodigital2024-08-30
dc.format.extent11 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1002/jpn3.12294
dc.identifier.scopusidSCOPUS_ID:85196621700
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/87166
dc.identifier.wosidWOS:001253871500001
dc.information.autorucEscuela de Medicina; De Toro Navarrete, Valeria Francisca; S/I; 1077854
dc.information.autorucEscuela de Medicina; Alberti, Gigliola; 0000-0002-8540-1326; 167316
dc.information.autorucEscuela de Medicina; Domínguez, Angélica; 0000-0001-7477-7574; 131798
dc.information.autorucEscuela de Medicina; Carrasco Negüe, Karina Andrea; S/I; 1030852
dc.information.autorucEscuela de Medicina; Casanello Toledo, Paola Cecilia; 0000-0002-2355-1476; 146772
dc.language.isoen
dc.nota.accesoContenido parcial
dc.revistaJournal of Pediatric Gastroenterology and Nutrition
dc.rightsacceso restringido
dc.subjectChildhood obesity
dc.subjectDHA supplementation
dc.subjectMaternal obesity
dc.subject.ods02 Zero hunger
dc.subject.ods03 Good health and well-being
dc.subject.odspa02 Hambre cero
dc.subject.odspa03 Salud y bienestar
dc.titleGrowth patterns in infants born to women with pregestational overweight/obesity supplemented with docosahexaenoic acid during pregnancy
dc.typeartículo
sipa.codpersvinculados1077854
sipa.codpersvinculados167316
sipa.codpersvinculados131798
sipa.codpersvinculados1030852
sipa.codpersvinculados146772
sipa.trazabilidadORCID;2024-07-15
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