Human Immunodeficiency Virus Type 1 (HIV-1) Induces the Cytoplasmic Retention of Heterogeneous Nuclear Ribonucleoprotein A1 by Disrupting Nuclear Import IMPLICATIONS FOR HIV-1 GENE EXPRESSION

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dc.contributor.authorMonette, Anne
dc.contributor.authorAjamian, Lara
dc.contributor.authorLopez Lastra, Marcelo
dc.contributor.authorMouland, Andrew J.
dc.date.accessioned2024-01-10T12:39:27Z
dc.date.available2024-01-10T12:39:27Z
dc.date.issued2009
dc.description.abstractHuman immunodeficiency virus type 1 (HIV-1) co-opts host proteins and cellular machineries to its advantage at every step of the replication cycle. Here we show that HIV-1 enhances heterogeneous nuclear ribonucleoprotein (hnRNP) A1 expression and promotes the relocalization of hnRNP A1 to the cytoplasm. The latter was dependent on the nuclear export of the unspliced viral genomic RNA (vRNA) and to alterations in the abundance and localization of the FG-repeat nuclear pore glycoprotein p62. hnRNP A1 and vRNA remain colocalized in the cytoplasm supporting a post-nuclear function during the late stages of HIV-1 replication. Consistently, we show that hnRNP A1 acts as an internal ribosomal entry site trans-acting factor up-regulating internal ribosome entry site-mediated translation initiation of the HIV-1 vRNA. The up-regulation and cytoplasmic retention of hnRNP A1 by HIV-1 would ensure abundant expression of viral structural proteins in cells infected with HIV-1.
dc.description.funderChilean Fondo Nacional de Ciencia y Techologia
dc.description.funderCanadian Foundation for Innovation
dc.description.funderCanadian Institutes of Health Research (CIHR)
dc.fechaingreso.objetodigital2024-05-09
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1074/jbc.M109.048736
dc.identifier.eissn1083-351X
dc.identifier.pubmedidMEDLINE:19737937
dc.identifier.urihttps://doi.org/10.1074/jbc.M109.048736
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/77194
dc.identifier.wosidWOS:000271378400061
dc.information.autorucMedicina;López-Lastra M;S/I;84823
dc.issue.numero45
dc.language.isoen
dc.nota.accesoSin adjunto
dc.pagina.final31362
dc.pagina.inicio31350
dc.publisherAMER SOC BIOCHEMISTRY MOLECULAR BIOLOGY INC
dc.revistaJOURNAL OF BIOLOGICAL CHEMISTRY
dc.rightsregistro bibliográfico
dc.subjectRNA-BINDING-PROTEIN
dc.subjectVIROLOGICAL SYNAPSE FORMATION
dc.subjectPORE COMPLEX COMPOSITION
dc.subjectMAJOR CAPSID PROTEIN
dc.subjectTRANS-ACTING FACTOR
dc.subjectHNRNP A/B PROTEINS
dc.subjectMESSENGER-RNA
dc.subjectGENOMIC RNA
dc.subjectCELL-CYCLE
dc.subjectTRANSLATION INITIATION
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHuman Immunodeficiency Virus Type 1 (HIV-1) Induces the Cytoplasmic Retention of Heterogeneous Nuclear Ribonucleoprotein A1 by Disrupting Nuclear Import IMPLICATIONS FOR HIV-1 GENE EXPRESSION
dc.typeartículo
dc.volumen284
sipa.codpersvinculados84823
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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