Forecasting Seizure Freedom After Epilepsy Surgery Assessing Concordance Between Noninvasive and StereoEEG Findings

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dc.catalogadorjlo
dc.contributor.authorUribe San Martin, Reinaldo
dc.contributor.authorDi Giacomo, Roberta
dc.contributor.authorMai, Roberto
dc.contributor.authorGozzo, Francesca
dc.contributor.authorPelliccia, Veronica
dc.contributor.authorMariani, Valeria
dc.contributor.authorCardinale, Francesco
dc.contributor.authorCiampi, Ethel
dc.contributor.authorOnofrj, Marco
dc.contributor.authorTassi, Laura
dc.date.accessioned2024-01-19T15:29:25Z
dc.date.available2024-01-19T15:29:25Z
dc.date.issued2021
dc.description.abstractBACKGROUND: Accurate localization of the probable Epileptogenic Zone (EZ) from presurgical studies is crucial for achieving good prognosis in epilepsy surgery. OBJECTIVE: To evaluate the degree of concordance at a sublobar localization derived from noninvasive studies (video electroencephalography, EEG; magnetic resonance imaging, MRI; 18-fluorodeoxyglucose positron emission tomography FDG-PET, FDG-PET) and EZ estimated by stereoEEG, in forecasting seizure recurrence in a long-term cohort of patients with focal drug-resistant epilepsy. METHODS: We selected patients with a full presurgical evaluation and with postsurgical outcome at least 1 yr after surgery. Multivariate Cox regression analysis for seizure freedom (Engel Ia) was performed. RESULTS: A total of 74 patients were included, 62.2% were in Engel class Ia with a mean follow-up of 2.8 + 2.4 yr after surgery. In the multivariate analysis for Engel Ia vs >Ib, complete resection of the EZ found in stereoEEG (hazard ratio, HR: 0.24, 95%CI: 0.09-0.63, P = .004) and full concordance between FDG-PET and stereoEEG (HR: 0.11, 95%CI: 0.02-0.65, P = .015) portended a more favorable outcome. Most of our results were maintained when analyzing subgroups of patients. CONCLUSION: The degree of concordance between noninvasive studies and stereoEEG may help to forecast the likelihood of cure before performing resective surgery, particularly using a sublobar classification and comparing the affected areas in the FDG-PET with EZ identified with stereoEEG.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1093/neuros/nyaa322
dc.identifier.issn0148-396X
dc.identifier.urihttp://dx.doi.org/10.1093/neuros/nyaa322
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80759
dc.identifier.wosidWOS:000776753800031
dc.information.autorucEscuela de Medicina; Uribe San Martín, Reinaldo Moisés; 0000-0002-3422-7962; 127201
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final121
dc.pagina.inicio113
dc.revistaNeurosurgery
dc.rightsacceso restringido
dc.subjectEpilepsy surgery
dc.subjectEpileptogenic zone
dc.subjectStereoEEG
dc.subjectFDG-PET
dc.subjectDrug-resistant epilepsy
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleForecasting Seizure Freedom After Epilepsy Surgery Assessing Concordance Between Noninvasive and StereoEEG Findings
dc.typeartículo
dc.volumen88
sipa.codpersvinculados127201
sipa.trazabilidadORCID;2024-01-08
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