Lentigo maligna melanoma mapping using reflectance confocal microscopy correlates with staged excision: A prospective study

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dc.contributor.authorNavarrete-Dechent, Cristian
dc.contributor.authorCordova, Miguel
dc.contributor.authorAleissa, Saud
dc.contributor.authorLiopyris, Konstantinos
dc.contributor.authorDusza, Stephen W.
dc.contributor.authorKose, Kivanc
dc.contributor.authorBusam, Klaus J.
dc.contributor.authorHollman, Travis
dc.contributor.authorLezcano, Cecilia
dc.contributor.authorPulitzer, Melissa
dc.contributor.authorChen, Chih-Shan J.
dc.contributor.authorLee, Erica H.
dc.contributor.authorRossi, Anthony M.
dc.contributor.authorNehal, Kishwer S.
dc.date.accessioned2025-01-20T20:11:08Z
dc.date.available2025-01-20T20:11:08Z
dc.date.issued2023
dc.description.abstractBackground: Lentigo maligna/lentigo maligna melanoma (LM/LMM) can present with subclinical extension that may be difficult to define preoperatively and lead to incomplete excision and potential recurrence. Preliminarily studies have used reflectance confocal microscopy (RCM) to assess LM/LMM margins.
dc.description.abstractObjective: To evaluate the correlation of LM/LMM subclinical extension defined by RCM compared with the gold standard histopathology.
dc.description.abstractMethods: Prospective study of LM/LMM patients referred for dermatologic surgery. RCM was performed at the clinically defined initial surgical margin followed by margin-controlled staged excision with paraffin-embedded tissue, and histopathology was correlated with RCM results.
dc.description.abstractResults: Seventy-two patients were included. Mean age was 66.8 years (standard deviation, 11.1; range, 38-89); 69.4% were men. Seventy of 72 lesions (97.2%) were located on the head and neck with mean largest clinical diameter of 1.3 cm (range, 0.3-5). Diagnostic accuracy for detection of residual melanoma in the tumor debulk (after biopsy) had a sensitivity of 96.7% and a specificity of 66.7% when compared with histopathology. RCM margin assessment revealed an overall agreement with final histopathology of 85.9% (k = 0.71; P < .001).
dc.description.abstractLimitations: No RCM imaging beyond initial planned margins was performed.
dc.description.abstractConclusion: RCM showed moderate to excellent overall agreement between RCM imaging of LM/LMM and histopathology of staged excision margins.
dc.description.funderNational Institutes of Health/National Cancer Institute Cancer Center Support Grant
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jaad.2019.11.058
dc.identifier.eissn1097-6787
dc.identifier.issn0190-9622
dc.identifier.urihttps://doi.org/10.1016/j.jaad.2019.11.058
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92123
dc.identifier.wosidWOS:000994416200001
dc.issue.numero2
dc.language.isoen
dc.pagina.final379
dc.pagina.inicio371
dc.revistaJournal of the american academy of dermatology
dc.rightsacceso restringido
dc.subjectlentigo maligna
dc.subjectmargins
dc.subjectmelanoma
dc.subjectMohs surgery
dc.subjectreflectance confocal microscopy
dc.subjectstaged excision
dc.subjectsurgery
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLentigo maligna melanoma mapping using reflectance confocal microscopy correlates with staged excision: A prospective study
dc.typeartículo
dc.volumen88
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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