Iron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study

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dc.article.numbere68833
dc.catalogadorjca
dc.contributor.authorMagalhaes Queiroz, Dulciene Maria
dc.contributor.authorHarris, Paul
dc.contributor.authorSanderson, Ian R.
dc.contributor.authorWindle, Henry J.
dc.contributor.authorWalker, Marjorie M.
dc.contributor.authorCamargos Rocha, Andreia Maria
dc.contributor.authorRocha, Gifone Aguiar
dc.contributor.authorCarvalho, Simone Diniz
dc.contributor.authorSouto Bittencourt, Paulo Fernando
dc.contributor.authorFonseca de Castro, Lucia Porto
dc.contributor.authorVillagran, Andrea
dc.contributor.authorSerrano, Carolina
dc.contributor.authorKelleher, Dermot
dc.contributor.authorCrabtree, Jean E.
dc.date.accessioned2024-01-19T15:25:19Z
dc.date.available2024-01-19T15:25:19Z
dc.date.issued2013
dc.description.abstractObjective: Iron deficiency (ID) and iron deficiency anaemia (IDA) are global major public health problems, particularly in developing countries. Whilst an association between H. pylori infection and ID/IDA has been proposed in the literature, currently there is no consensus. We studied the effects of H. pylori infection on ID/IDA in a cohort of children undergoing upper gastrointestinal endoscopy for upper abdominal pain in two developing and one developed country. Methods: In total 311 children (mean age 10.7±3.2 years) from Latin America - Belo Horizonte/Brazil (n = 125), Santiago/Chile (n = 105) - and London/UK (n = 81), were studied. Gastric and duodenal biopsies were obtained for evaluation of histology and H. pylori status and blood samples for parameters of ID/IDA. Results: The prevalence of H. pylori infection was 27.7% being significantly higher (p<0.001) in Latin America (35%) than in UK (7%). Multiple linear regression models revealed H. pylori infection as a significant predictor of low ferritin and haemoglobin concentrations in children from Latin-America. A negative correlation was observed between MCV (r = −0.26; p = 0.01) and MCH (r = −0.27; p = 0.01) values and the degree of antral chronic inflammation, and between MCH and the degree of corpus chronic (r = −0.29, p = 0.008) and active (r = −0.27, p = 0.002) inflammation. Conclusions: This study demonstrates that H. pylori infection in children influences the serum ferritin and haemoglobin concentrations, markers of early depletion of iron stores and anaemia respectively.
dc.fuente.origenORCID-ene24
dc.identifier.doi10.1371/JOURNAL.PONE.0068833
dc.identifier.issn1932-6203
dc.identifier.urihttps://doi.org/10.1371/JOURNAL.PONE.0068833
dc.identifier.urihttps://publons.com/wos-op/publon/27288954/
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/80723
dc.identifier.wosidWOS:000323350700104
dc.information.autorucEscuela de Medicina; Harris Diez, Paul Richard; 0000-0001-6226-0957; 80706
dc.information.autorucEscuela de Enfermería;Villagran Torres, Andrea Alejandra;S/I;1004414
dc.information.autorucEscuela de Enfermería;Serrano Honeyman, Carolina Andrea;0000-0001-5523-0637;15296
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final6
dc.pagina.inicio1
dc.revistaPlos One
dc.rightsacceso abierto
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleIron Status and Helicobacter pylori Infection in Symptomatic Children: An International Multi-Centered Study
dc.typeartículo
dc.volumen8
sipa.codpersvinculados80706
sipa.codpersvinculados1004414
sipa.codpersvinculados15296
sipa.trazabilidadORCID;2024-01-08
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