Differential phase-amplitude coupling in nucleus accumbens and orbitofrontal cortex reflects decision-making during a delay discounting task

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dc.contributor.authorAzocar, V. H.
dc.contributor.authorPetersson, P.
dc.contributor.authorFuentes, R.
dc.contributor.authorFuentealba, J. A.
dc.date.accessioned2025-01-20T16:13:31Z
dc.date.available2025-01-20T16:13:31Z
dc.date.issued2024
dc.description.abstractBackground: The impulsive choice is characterized by the preference for a small immediate reward over a bigger delayed one. The mechanisms underlying impulsive choices are linked to the activity in the Nucleus Accumbens (NAc), the orbitofrontal cortex (OFC), and the dorsolateral striatum (DLS). While the study of functional connectivity between brain areas has been key to understanding a variety of cognitive processes, it remains unclear whether functional connectivity differentiates impulsive-control decisions.
dc.description.abstractMethods: To study the functional connectivity both between and within NAc, OFC, and DLS during a delay discounting task, we concurrently recorded local field potential in NAc, OFC, and DLS in rats. We then quantified the degree of phase-amplitude coupling (PAC), coherence, and Granger Causality between oscillatory activities in animals exhibiting either a high (HI) or low (LI) tendency for impulsive choices.
dc.description.abstractResults: Our results showed a differential pattern of PAC during decision-making in OFC and NAc, but not in DLS. While theta-gamma PAC in OFC was associated with self-control decisions, a higher delta-gamma PAC in both OFC and NAc biased decisions toward impulsive choices in both HI and LI groups. Furthermore, during the reward event, Granger Causality analysis indicated a stronger NAc.OFC gamma contribution in the HI group, while the LI group showed a higher OFC.NAc gamma contribution.
dc.description.abstractConclusions: The overactivity in NAc during reward in the HI group suggests that exacerbated contribution of NAcCore can lead to an overvaluation of reward that biases the behavior toward the impulsive choice.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.pnpbp.2024.111064
dc.identifier.eissn1878-4216
dc.identifier.issn0278-5846
dc.identifier.urihttps://doi.org/10.1016/j.pnpbp.2024.111064
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/90391
dc.identifier.wosidWOS:001264360300001
dc.language.isoen
dc.revistaProgress in neuro-psychopharmacology & biological psychiatry
dc.rightsacceso restringido
dc.subjectDelay discounting
dc.subjectImpulsivity
dc.subjectPhase-amplitude coupling
dc.subjectElectrophysiology
dc.subjectOrbitofrontal cortex
dc.subjectNucleus Accumbens
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDifferential phase-amplitude coupling in nucleus accumbens and orbitofrontal cortex reflects decision-making during a delay discounting task
dc.typeartículo
dc.volumen134
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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