Lack of association between helicobacter pylori and pediatric atopy: evidence from a latin american multicenter cohort

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dc.catalogadordfo
dc.contributor.authorGil Galleguillos, Pamela Yanet
dc.contributor.authorRojo, Claudia
dc.contributor.authorLara Martín, Manuel
dc.contributor.authorAguilera-Matos, Idalmis
dc.contributor.authorVásconez, Fabian
dc.contributor.authorManríquez, Emma
dc.contributor.authorGonzález, Dominga
dc.contributor.authorMontoya, Nicole
dc.contributor.authorHernández, Pamela
dc.contributor.authorSerrano, Carolina A.
dc.contributor.authorCastro Rodríguez, José Antonio
dc.contributor.authorHarris, Paul R.
dc.date.accessioned2025-11-25T19:12:25Z
dc.date.available2025-11-25T19:12:25Z
dc.date.issued2025
dc.description.abstractObjectives: Owing to the regulatory effect of the immune response associatedwith Helicobacter pylori, a protective role for this infection in the developmentof atopic conditions in children has been postulated. We aim to study thepotential inverse association between H. pylori infection and the presence ofasthma/rhinitis/eczema in Latin American children.Methods: This was a cross‐sectional study with prospective recruitment ofconsecutive symptomatic patients referred for endoscopy in Cuba, Ecuador,and Chile. Demographic data and asthma, rhinitis, and eczema (InternationalStudy of Asthma and Allergies in Childhood III) questionnaires were adminis-tered. Atopy was defined as the presence of at least one of the three diseases.A child was considered H. pylori‐infected if one endoscopy‐based invasive testresult was positive. Multiple regression model analyses were performed.Results: Two hundred fifty‐one patients were enrolled. Of these, 53% weremale, aged 11 ± 2.7 years. Additionally, 114 (45%) were infected by H. pylori,and 141 (56.2%) had some atopic condition, with no differences by country.Atopy was more prevalent in males than females (59% vs. 41%, p < 0.05). Nosignificant association was observed between atopy and the presence of H.pylori: 68 (59.6%) infected children presented with atopy compared to 73(53.3%) uninfected children. Logistic regression showed that H. pylori infectionwas positively associated with age (odds ratio [OR]: 1.21 [1.05–1.42],p = 0.0117) and rhinitis (OR: 1.89 [1.08–3.35], p = 0.0279) and negativelyassociated with eosinophilic esophagitis (OR: 0.11 [0.01–0.65], p = 0.042).Conclusions: In this study, H. pylori‐infected and uninfected children pre-sented similar frequencies of atopy. Further studies with larger cohorts areneeded to clarify the role of H. pylori in atopic conditions
dc.fuente.origenORCID
dc.identifier.doi10.1002/JPN3.70237
dc.identifier.issn0277-2116
dc.identifier.urihttps://doi.org/10.1002/JPN3.70237
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107106
dc.information.autorucEscuela de Medicina; Serrano Honeyman, Carolina Andrea; 0000-0001-5523-0637; 15296
dc.information.autorucEscuela de Medicina; Gil Galleguillos Pamela Yanet; S/I; 1046383
dc.information.autorucEscuela de Medicina; Castro Rodriguez Jose Antonio; 0000-0002-0708-4281; 113247
dc.language.isoen
dc.nota.accesoContenido parcial
dc.rightsAcceso restringido
dc.subjectAsthma
dc.subjectEczema
dc.subjectEosinophilic esophagitis
dc.subjectH. pylori infection
dc.subjectRhinitis
dc.subject.ddc610
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLack of association between helicobacter pylori and pediatric atopy: evidence from a latin american multicenter cohort
dc.typeartículo
sipa.codpersvinculados15296
sipa.codpersvinculados1046383
sipa.codpersvinculados113247
sipa.trazabilidadORCID;2025-11-24
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