Beyond ECMO Survival: Long-Term Symptom Burden and Quality-of-Life Impairment in Hantavirus Cardiopulmonary Syndrome Survivors

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dc.article.number1241
dc.catalogadorgrr
dc.contributor.authorValenzuela Galaz, Gonzalo Hernan
dc.contributor.authorBarahona, Katherine
dc.contributor.author Rojas, Camila
dc.contributor.author Barrera, Aldo
dc.contributor.authorHenríquez, Carolina
dc.contributor.authorMartínez-Valdebenito, Constanza
dc.contributor.author Potin, Marcela
dc.contributor.authorBedregal, Paula
dc.contributor.author Ferrés, Marcela
dc.date.accessioned2025-09-24T19:35:30Z
dc.date.available2025-09-24T19:35:30Z
dc.date.issued 2025
dc.description.abstractAndes virus (ANDV) is the leading cause of hantavirus cardiopulmonary syndrome (HCPS) in South America, a severe zoonosis with high mortality. Advances in critical care and extracorporeal membrane oxygenation (ECMO) have significantly improved survival rates; however, data on recovery beyond survival remain limited. This multicenter cohort study enrolled laboratory-confirmed HCPS survivors in Chile between 2021 and 2024, with follow-up at 3–6 months post-symptom onset to assess physical and neuropsychological sequelae. Participants were stratified by ECMO requirement and the clinical severity of HCPS, and evaluated using self-reported recovery, standardized symptom questionnaires, and EQ-5D quality-of-life instruments. Among 21 survivors (11 ECMO, 10 non-ECMO), 61.9% reported incomplete recovery. While 60–70% of patients received general medical follow-up, only 30% of non-ECMO patients—compared to all ECMO patients—had contact with a rehabilitation provider. Motor dysfunction and palpitations were more frequent in ECMO survivors; however, Jaccard index analysis revealed clustering of physical and neuropsychological symptoms across both groups. EQ-5D assessments showed comparable quality-of-life impairment, though non-ECMO survivors more often reported pain/discomfort (90.0% vs. 63.6%) and higher rates of analgesic self-medication. These findings highlight the burden of persistent symptoms after HCPS and the need for multidisciplinary post-discharge care in endemic regions.
dc.fechaingreso.objetodigital2025-09-24
dc.format.extent15 páginas
dc.fuente.origenORCID
dc.identifier.doi10.3390/v17091241
dc.identifier.issn1999-4915
dc.identifier.urihttps://doi.org/10.3390/v17091241
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105750
dc.information.autorucDepartamento de Salud Pública, Escuela de Medicina; Bedregal, Paula; 0000-0003-3550-9117; 79369
dc.information.autorucEscuela de Medicina; Valenzuela Galaz, Gonzalo Hernan; 0000-0002-5538-8749; 213128
dc.issue.numero9
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaViruses
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectHantaviridae
dc.subjectHantavirus cardiopulmonary syndrome
dc.subjectRodent-borne viruses
dc.subjectPost-acute sequela
dc.subjectLong-term symptoms
dc.subjectZoonosis
dc.subjectVirus–host interaction
dc.subjectExtracorporeal membrane oxygenation
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBeyond ECMO Survival: Long-Term Symptom Burden and Quality-of-Life Impairment in Hantavirus Cardiopulmonary Syndrome Survivors
dc.typeartículo
dc.volumen17
sipa.codpersvinculados213128
sipa.codpersvinculados79369
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