RELATIVE CONTRIBUTION OF CAROTID AND AORTIC BODIES TO CYANIDE-INDUCED VENTILATORY RESPONSES IN THE CAT

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dc.contributor.authorSERANI, A
dc.contributor.authorZAPATA, P
dc.date.accessioned2025-01-23T19:44:13Z
dc.date.available2025-01-23T19:44:13Z
dc.date.issued1981
dc.description.abstractThe participation of afferences from carotid and aortic bodies to the hyperventilation caused by cytotoxic hypoxia was assessed in pentobarbitone-anesthetized cats. Dose-response curves for the ventilatory effects induced by i.v. injections of NaCN were obtained before and after successive denervations of peripheral chemoreceptors, in different sequences. Bilateral aortic neurotomy (BAN) or unilateral carotid neurotomy (UCN) did not affect significantly the minimal sensitivity to the drug, although maximal reactivity was reduced in some cats. After bilateral carotid neurotomy (BCN), with preservation of aortic nerves, sensitivity was reduced, but hyperventilation was still provoked by large doses of CN. BAN + BCN abolished the ventilatory responses to the drug. In cats with BAN + UCN, ventilatory responses had a high degree of correlation with increases of carotid chemosensory discharges in the range between 200% of control and the gasping threshold. The aortic bodies of the cat play a significant role in the hyperventilation produced by cytotoxic hypoxia, although it is less marked than that induced through the carotid bodies.
dc.fuente.origenWOS
dc.identifier.issn0003-9780
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99979
dc.identifier.wosidWOS:A1981MH10400011
dc.issue.numero2
dc.language.isoen
dc.pagina.final297
dc.pagina.inicio284
dc.revistaArchives internationales de pharmacodynamie et de therapie
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRELATIVE CONTRIBUTION OF CAROTID AND AORTIC BODIES TO CYANIDE-INDUCED VENTILATORY RESPONSES IN THE CAT
dc.typeartículo
dc.volumen252
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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