Honeybee Pollen Extracts Reduce Oxidative Stress and Steatosis in Hepatic Cells.

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dc.contributor.authorNunez-Pizarro, Paula
dc.date.accessioned2023-05-19T20:49:47Z
dc.date.available2023-05-19T20:49:47Z
dc.date.issued2020
dc.description.abstractNonalcoholic fatty liver disease (NAFLD) is a major cause of morbidity and mortality worldwide. Additional therapies using functional foods and dietary supplements have been investigated and used in clinical practice, showing them to be beneficial. Honeybee pollen from Chile has shown a large concentration of phenolic compounds and high antioxidant activity. In this work, we characterized twenty-eight bee pollen extracts from the central zone of Chile according to botanical origin, phenolic profile, quercetin concentration, and antioxidant activity (FRAP and ORAC-FL). Our results show a statistically significant positive correlation between total phenolic content and antioxidant capacity. Selected samples were evaluated on the ability to reverse the steatosis in an in vitro cell model using Hepa1-6 cells. The pollen extracts protected Hepa1-6 cells against oxidative damage triggered by 2,2 '-azo-bis(2-amidinopropane) dihydrochloride (AAPH)derived free radicals. This effect can be credited to the ability of the phenolic compounds present in the extract to protect the liver cells from chemical-induced injury, which might be correlated to their free radical scavenging potential. Additionally, bee pollen extracts reduce lipid accumulation in a cellular model of steatosis. In summary, our results support the antioxidant, hepatoprotective, and anti-steatosis effect of bee pollen in an in vitro model.
dc.fechaingreso.objetodigital2024-12-20
dc.fuente.origenORCID-mayo23
dc.identifier.doi10.3390/molecules26010006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/70059
dc.identifier.urihttps://doi.org/10.3390/molecules26010006
dc.identifier.wosidWOS:000606220500001
dc.issue.numeroNo. 1
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaMolecules
dc.rightsacceso abierto
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHoneybee Pollen Extracts Reduce Oxidative Stress and Steatosis in Hepatic Cells.es_ES
dc.typeartículo
dc.volumenVol. 26
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