Circulating Bilirubin Levels, but Not Their Genetic Determinants, Are Inversely Associated with Steatotic Liver Disease in Adolescents

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dc.article.number2980
dc.contributor.authorMiranda Marin, Jose Patricio
dc.contributor.authorGana, Juan Carlos
dc.contributor.authorAlberti, Gigliola
dc.contributor.authorGalindo Muñoz, Karen Melissa
dc.contributor.authorPereira, Ana
dc.contributor.authorSantos Martín, José Luis
dc.date.accessioned2025-05-01T10:31:07Z
dc.date.available2025-05-01T10:31:07Z
dc.date.issued2025
dc.description.abstractEpidemiologic studies suggest that elevated plasma unconjugated bilirubin confer protection against steatotic liver disease (SLD) in adults. However, evidence supporting this protective role in adolescents remains limited. We aimed to assess the association between serum bilirubin levels and their genetic determinants in protecting against SLD in Chilean adolescents. We conducted a cross-sectional study with 704 adolescents aged 15.4 ± 1 years (52% girls) of the Chilean Growth and Obesity Cohort Study. Ultrasonography echogenicity was used to diagnose SLD. We measured Z-scores of body mass index (z-BMI), total bilirubin (TB), and the genetic determinants of bilirubin (including rs887829 genotypes of UGT1A1 and bilirubin polygenic scores). Multiple logistic regression models evaluated the associations between standardized TB and its genetic determinants with SLD. We found that 1-SD of standardized plasma TB was significantly associated with a 30% reduction in the likelihood of SLD after adjustment by sex, age, z-BMI, and ethnicity (OR = 0.7; 95% CI = 0.50–0.96; p = 0.03). No significant associations were found among the rs887829 genotypes, bilirubin polygenic scores, and SLD in logistic regression models adjusted by covariates. Increased circulating bilirubin levels are unlikely causally associated with protection against SLD, and the cross-sectional association could be due to unmeasured confounding.
dc.description.funderComisión Nacional de Investigación Científica y Tecnológica de Chile CONICYT
dc.description.funderISCIII
dc.description.funderAgencia Nacional de Investigación y Desarrollo de Chile ANID
dc.description.funderPontificia Universidad Católica de Chile
dc.description.funderERDF
dc.description.funderFONDECYT
dc.description.funderSpanish National Cancer Research Centre
dc.format.extent21 páginas
dc.fuente.origenScopus
dc.identifier.doi10.3390/ijms26072980
dc.identifier.eisbn978-1-5106-5352-8
dc.identifier.eissn1422-0067
dc.identifier.isbn978-1-5106-5351-1
dc.identifier.issn0360-5442
dc.identifier.pubmedid40243597
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:105002308258
dc.identifier.urihttps://doi.org/10.3390/ijms26072980
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103715
dc.identifier.wosidWOS:001463906500001
dc.information.autorucEscuela de Medicina; Miranda Marin, Jose Patricio; 0000-0002-8270-1112; 1126717
dc.information.autorucEscuela de Medicina; Alberti, Gigliola; 0000-0002-8540-1326; 167316
dc.information.autorucEscuela de Medicina; Galindo Muñoz, Karen Melissa; S/I; 1183077
dc.information.autorucEscuela de Medicina; Santos Martín, José Luis; 0000-0003-2895-0369; 1005923
dc.issue.numero7
dc.language.isoen
dc.nota.accesoContenido completo
dc.pagina.final22
dc.pagina.inicio14
dc.relation.ispartofJCO global oncology
dc.revistaInternational Journal of Molecular Sciences
dc.rightsacceso abierto
dc.subjectBilirubin
dc.subjectNative American ancestry
dc.subjectPolygenic scores
dc.subjectSteatotic liver disease
dc.subjectUGT1A1
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods09 Industry, innovation and infrastructure
dc.subject.odspa09 Industria, innovación e infraestructura
dc.titleCirculating Bilirubin Levels, but Not Their Genetic Determinants, Are Inversely Associated with Steatotic Liver Disease in Adolescents
dc.typeartículo
dc.volumen26
sipa.codpersvinculados1126717
sipa.codpersvinculados167316
sipa.codpersvinculados1183077
sipa.codpersvinculados1005923
sipa.indexScopus
sipa.indexPubmed
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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