Reduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid

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dc.contributor.authorEisen, Damon P.
dc.contributor.authorCorey, G. Ralph
dc.contributor.authorMcBryde, Emma S.
dc.contributor.authorFowler, Vance G.
dc.contributor.authorMiro, Jose M.
dc.contributor.authorCabell, Chris H.
dc.contributor.authorStreet, Alan C.
dc.contributor.authorPaiva, Marcelo Goulart
dc.contributor.authorIonac, Adina
dc.contributor.authorTan, Ru San
dc.contributor.authorTribouilloy, Christophe
dc.contributor.authorPachirat, Orathai
dc.contributor.authorBraun Jones, Sandra
dc.contributor.authorChipigina, Natalia
dc.contributor.authorNaber, Christoph
dc.contributor.authorPan, Angelo
dc.contributor.authorRavasio, Veronica
dc.contributor.authorGattringer, Rainer
dc.contributor.authorChu, Vivian H.
dc.contributor.authorBayer, Arnold S.
dc.contributor.authorICE Investigators
dc.date.accessioned2024-01-10T13:17:07Z
dc.date.available2024-01-10T13:17:07Z
dc.date.issued2009
dc.description.abstractObjectives: To assess the influence of acetyl-salicylic acid (ASA) on clinical outcomes in Staphylococcus aureus infective endocarditis (SA-IE).
dc.description.abstractMethods: The International Collaboration on Endocarditis - Prospective Cohort Study database was used in this observational study. Multivariable analysis of the SA-IE cohort compared outcomes in patients with and without ASA use, adjusting for other predictive variables, including: age, diabetes, hemodialysis, cancer, pacemaker, intracardiac defibrillator and methicillin resistance.
dc.description.abstractResults: Data were analysed from 670 patients, 132 of whom were taking ASA at the time of SA-IE diagnosis. On multivariable analysis, ASA usage was associated with a significantly decreased overall rate of acute valve replacement surgery (OR 0.58 [95% CI 0.35-0.97]; p < 0.04), particularly where valvular regurgitation, congestive heart failure or periannular abscess was the indication for such surgery (OR 0.46 [0.25-0.86]; p < 0.02). There was no reduction in the overall rates of clinically apparent embolism with prior ASA usage, and no increase in hemorrhagic strokes in ASA-treated patients.
dc.description.abstractConclusions: In this multinational prospective observational cohort, recent ASA usage was associated with a reduced occurrence of acute valve replacement surgery in SA-IE patients. Future investigations should focus on ASA's prophylactic and therapeutic use in high-risk and newly diagnosed patients with SA bacteremia and SA-IE, respectively. Crown Copyright (C) 2009 Published by Elsevier Ltd on behalf of The British Infection Society. All rights reserved.
dc.description.funderNATIONAL INSTITUTE OF ALLERGY AND INFECTIOUS DISEASES
dc.description.funderNIAID NIH HHS
dc.fechaingreso.objetodigital27-03-2024
dc.format.extent7 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jinf.2009.03.006
dc.identifier.eissn1532-2742
dc.identifier.issn0163-4453
dc.identifier.pubmedidMEDLINE:19342103
dc.identifier.urihttps://doi.org/10.1016/j.jinf.2009.03.006
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/78639
dc.identifier.wosidWOS:000266460000003
dc.information.autorucMedicina;Braun S;S/I;99111
dc.issue.numero5
dc.language.isoen
dc.nota.accesocontenido parcial
dc.pagina.final338
dc.pagina.inicio332
dc.publisherW B SAUNDERS CO LTD
dc.revistaJOURNAL OF INFECTION
dc.rightsacceso restringido
dc.subjectStaphylococcus aureus
dc.subjectEndocarditis
dc.subjectAcetyl-salicylic acid
dc.subjectSurgery
dc.subjectINTERNATIONAL COLLABORATION
dc.subjectINFECTIVE ENDOCARDITIS
dc.subjectEMBOLIC EVENTS
dc.subjectCARDIOVASCULAR-DISEASE
dc.subjectANTIPLATELET THERAPY
dc.subjectALPHA-TOXIN
dc.subjectASPIRIN
dc.subjectRISK
dc.subjectDIAGNOSIS
dc.subjectVIRULENCE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReduced valve replacement surgery and complication rate in Staphylococcus aureus endocarditis patients receiving acetyl-salicylic acid
dc.typeartículo
dc.volumen58
sipa.codpersvinculados99111
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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