Photophysical characterization of tetrahydroxyphenyl porphyrin Zn(II) and V(IV) complexes: experimental and DFT study

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dc.contributor.authorDiaz-Uribe, Carlos
dc.contributor.authorRangel, Daily
dc.contributor.authorVallejo, William
dc.contributor.authorValle, Roger
dc.contributor.authorHidago-Rosa, Yoan
dc.contributor.authorZarate, Ximena
dc.contributor.authorSchott, Eduardo
dc.date.accessioned2025-01-20T20:09:54Z
dc.date.available2025-01-20T20:09:54Z
dc.date.issued2023
dc.description.abstractPhotodynamic therapy (PDT) is a promising technique for the treatment of various diseases. In this sense, the singlet oxygen quantum yield (& phi;( increment )) is a physical-chemical property that allows to stablish the applicability of a potential photosensitizers (PS) as a drug for PDT. In the herein report, the & phi;( increment ) of three photosensitizers was determined: metal-free tetrahydroxyphenyl porphyrin (THPP), THPP-Zn and the THPP-V metal complexes. Their biological application was also evaluated. Therefore, the in vitro study was carried out to assess their biological activity against Escherichia coli. The metal-porphyrin complexes exhibited highest activities against the bacterial strain Escherichia coli. at the highest concentration (175 & mu;g/mL) and show better activity than the free base ligand (salts and blank solution). Results indicated a relation between & phi;( increment ) and the inhibitory activity against Escherichia coli, thus, whereas higher is the & phi;( increment ), higher is the inhibitory activity. The values of the & phi;( increment ) and the inhibitory activity follows the tendency THPP-Zn > THPP > THPP-V. Furthermore, quantum chemical calculations allowed to gain deep insight into the electronic and optical properties of THPP-Zn macrocycle, which let to verify the most probable energy transfer pathway involved in the singlet oxygen generation.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s10534-023-00514-9
dc.identifier.eissn1572-8773
dc.identifier.issn0966-0844
dc.identifier.urihttps://doi.org/10.1007/s10534-023-00514-9
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/92028
dc.identifier.wosidWOS:001013713100001
dc.issue.numero6
dc.language.isoen
dc.pagina.final1272
dc.pagina.inicio1257
dc.revistaBiometals
dc.rightsacceso restringido
dc.subjectPorphyrins
dc.subjectMetalloporphyrins
dc.subjectDFT
dc.subjectEscherichia coli
dc.subjectPhotosensitizer
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePhotophysical characterization of tetrahydroxyphenyl porphyrin Zn(II) and V(IV) complexes: experimental and DFT study
dc.typeartículo
dc.volumen36
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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