Association between GIP levels after glucose load and HMW adiponectin in normoglycemic women

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dc.article.numberEC-25-0804
dc.catalogadorvzp
dc.contributor.authorSalvatierra Matzner, Isidora
dc.contributor.authorParada, Javier
dc.contributor.authorCataldo Bascuñan, Luis Rodrigo
dc.contributor.authorGalgani Fuentes, José
dc.contributor.authorAlberti, Gigliola
dc.contributor.authorLabayen, Idoia
dc.contributor.authorLorenzoni Santos, José Guillermo
dc.date.accessioned2026-01-08T14:19:52Z
dc.date.available2026-01-08T14:19:52Z
dc.date.issued2025
dc.description.abstractBackground/Objectives: Glucose-dependent insulinotropic polypeptide (GIP) is secreted by enteroendocrine K cells in response to nutrient ingestion. The aims of this study are: 1) to evaluate the cross-sectional associations between plasma GIP change in response to an oral glucose challenge (as a surrogate of GIP secretion) with obesity-related anthropometric measurements, fasting inflammatory biomarkers, and fasting circulating adipokines. 2) to evaluate the feasibility of using postprandial plasma GIP as a biomarker of adiposity-related phenotypes in response to starchbased meals. Methods: Fifty normoglycemic women without obesity (19-32 years) were evaluated with an oral glucose tolerance test (OGTT). A feasibility study was conducted in a subset of eight women to estimate responses to starch-based meals (25 g of starch). Postprandial glycemic-related changes in plasma hormones/metabolites were assessed, as well as circulating adipokines and inflammatory biomarkers in fasting conditions. Results: The Incremental-GIP change after 2-hour OGTT was significantly associated with waist circumference (rho=0.34; P=0.02), fasting plasma TNFα (rho=0.54; P=0.0002), and white blood cell count (rho=0.39; P=0.008), but not with MCP-1, total adiponectin, leptin, or the free leptin index. A strong inverse association was found between incremental-GIP change and fasting plasma High-Molecular-Weight (HMW) Adiponectin (rho = -0.50; P = 0.0004), which remained significant after adjusting for age and body mass index. Conclusion: An inverse association was found between postprandial GIP levels and circulating HMW-adiponectin levels in humans. This research highlights the suitability of using postprandial plasma GIP as a biomarker for metabolic disturbances of increased adiposity, even in the absence of obesity.
dc.fechaingreso.objetodigital2026-01-08
dc.format.extent33 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1530/EC-25-0804
dc.identifier.eissn2049-3614
dc.identifier.urihttps://doi.org/10.1530/EC-25-0804
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/107591
dc.information.autorucDepartamento de Ciencias de la Salud; Salvatierra Matzner, Isidora; 0009-0000-2326-6715; 222172
dc.information.autorucEscuela de Medicina; Cataldo Bascuñan, Luis Rodrigo; 0000-0003-1225-414X; 1015508
dc.information.autorucDepartamento de Ciencias de la Salud; Galgani Fuentes, Jose Eduardo; 0000-0001-9793-8561; 1011272
dc.information.autorucEscuela de Medicina; Alberti Reus, Gigliola Loredana; 0000-0002-8540-1326; 167316
dc.information.autorucEscuela de Medicina; Lorenzoni Santos, José Guillermo; S/I; 80739
dc.language.isoen
dc.nota.accesocontenido completo
dc.revistaEndocrine Connections
dc.rightsacceso abierto
dc.rights.licenseAttribution 4.0 International (CC BY 4.0)
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/
dc.subjectIncretins
dc.subjectAdiponectin
dc.subjectHigh molecular weight adiponectin
dc.subjectGIP
dc.subjectAdipokines
dc.subject.ddc610
dc.subject.ods03 Good health and well-being
dc.subject.ods02 Zero hunger
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa02 Hambre cero
dc.titleAssociation between GIP levels after glucose load and HMW adiponectin in normoglycemic women
dc.typeartículo
sipa.codpersvinculados222172
sipa.codpersvinculados1015508
sipa.codpersvinculados1011272
sipa.codpersvinculados167316
sipa.codpersvinculados80739
sipa.trazabilidadORCID;2026-01-05
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