Plasma insulin-like growth factor-II (IGF-II) and IGF-II/IGF-I ratio in a chilean case of Doege-Potter Syndrome

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dc.catalogadorvdr
dc.contributor.authorTobar Durán, Hugo Eduardo
dc.contributor.authorIbaceta Gómez, Rodrigo Andrés
dc.contributor.authorFigueroa Toledo, Ana María
dc.contributor.authorQuiñones Tobar, Verónica Pilar
dc.contributor.authorIñiguez, Germán
dc.contributor.authorSalman, Patricio
dc.contributor.authorSerrano Larrea, Valentina Paz
dc.contributor.authorSalinas Fernández, Lorena Del Pilar
dc.contributor.authorSantos Martin, José Luis
dc.date.accessioned2025-09-10T19:45:56Z
dc.date.available2025-09-10T19:45:56Z
dc.date.issued2023
dc.description.abstractDoege-Potter syndrome is a rare clinical entity characterized by recurrent hypoglycemic events caused by non-pancreatic tumors secreting an incompletely processed high-molecular-weight form of Insulin-like Growth factor-II (IGF-II). To report IGF-II and IGF-I circulating levels in a Chilean case of Doege-Potter syndrome and control individuals, and to identify the high-molecular-weight form of IGF-II. We measured IGF-II and IGF-I plasma levels using enzyme-linked immunoassays (ELISA) in the patient and ten controls. We identified the high-molecular-weight form of IGF-II performed by Western blot. The plasma concentration of IGF-II in the patient was 868.9 ng/mL, which is only slightly > 80th percentile of controls (681,4 ± 212,8 ng/mL; mean ± standard deviation). In contrast, IGF-I plasma concentration in the patient was 17.6 ng/mL, which is notoriously lower than the corresponding levels in controls (109.1 ± 19.1 ng/mL). The IGF-II/IGF-I ratio in the patient was 49.4 (normal value < 10), which is 7.8 times higher compared to the average ratio of controls (6.3 ± 1.5). The high-molecular form of IGF-II presence in samples was confirmed through Western blot.
dc.fechaingreso.objetodigital2025-09-10
dc.format.extent5 páginas
dc.fuente.origenSCOPUS
dc.identifier.doi10.4067/s0034-98872023001001406
dc.identifier.issn0717-6163
dc.identifier.scopusidSCOPUS_ID:85200433273
dc.identifier.urihttps://doi.org/10.4067/s0034-98872023001001406
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105654
dc.information.autorucFacultad de Ciencias Biológicas; Tobar Durán, Hugo Eduardo; 0000-0002-9958-6253; 181479
dc.information.autorucFacultad de Ciencias Biológicas; Ibaceta Gómez, Rodrigo Andrés; S/I; 234233
dc.information.autorucEscuela de Medicina; Figueroa Toledo, Ana María; S/I; 237627
dc.information.autorucEscuela de Medicina; Quiñones Tobar, Verónica Pilar; S/I; 1002010
dc.information.autorucEscuela de Medicina; Serrano Larrea, Valentina Paz; S/I; 11709
dc.information.autorucEscuela de Medicina; Salinas Fernández, Lorena Del Pilar; S/I; 227708
dc.information.autorucEscuela de Medicina; Santos Martin, José Luis; 0000-0003-2895-0369; 1005923
dc.issue.numero10
dc.language.isoen
dc.pagina.final1410
dc.pagina.inicio1406
dc.revistaRevista Medica de Chile
dc.rightsacceso abierto
dc.rights.licenseCC BY 4.0 Attribution 4.0 International
dc.rights.urihttps://creativecommons.org/licenses/by/4.0/deed.en
dc.subjectHypoglycemia
dc.subjectIGF type 2
dc.subjectInsulin-like growth factor I
dc.subjectPleural
dc.subjectReceptor
dc.subjectSolitary fibrous tumor
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titlePlasma insulin-like growth factor-II (IGF-II) and IGF-II/IGF-I ratio in a chilean case of Doege-Potter Syndrome
dc.title.alternativeFactor de crecimiento similar a la insulina-II (IGF-II) y razón IGF-II/ IGF-I en un caso chileno de síndrome de Doege-Potter
dc.typeartículo
dc.volumen151
sipa.codpersvinculados181479
sipa.codpersvinculados234233
sipa.codpersvinculados237627
sipa.codpersvinculados1002010
sipa.codpersvinculados11709
sipa.codpersvinculados227708
sipa.codpersvinculados1005923
sipa.trazabilidadSCOPUS;2024-08-25
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