Hantavirus Gc glycoprotein: evidence for a class II fusion protein

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dc.contributor.authorTischler, ND
dc.contributor.authorGonzalez, A
dc.contributor.authorPerez-Acle, T
dc.contributor.authorRosemblatt, M
dc.contributor.authorValenzuela, PDT
dc.date.accessioned2025-01-21T01:06:39Z
dc.date.available2025-01-21T01:06:39Z
dc.date.issued2005
dc.description.abstractHantavirus cell entry is promoted by its envelope glycoproteins, Gin and Gc, through cell attachment and by fusion between viral and endosomal membranes at low pH. However, the role of Gn and Gc in receptor binding and cell fusion has not yet been defined. In this work, a sequence presenting characteristics similar to those of class II fusion peptides (FPs) of alphavirus Ell and flavivirus E proteins is identified within the hantavirus Gc glycoprotein. A three-dimensional comparative molecular model based on crystallographic data of tick-borne encephalitis virus E protein is proposed for the Andes virus (ANDV) Gc ectodomain, which supports a feasible class II fusion-protein fold. In vitro experimental evidence is provided for the binding activity of the ANDV FP candidate to artificial membranes, as demonstrated by fluorescence anisotropy assays. Taken together, these results support the hypothesis that the Gc glycoprotein of hantaviruses and of other members of the family Bunyaviridae directs the viral fusion activity and that it may be classified as a class II viral fusion protein.
dc.fuente.origenWOS
dc.identifier.doi10.1099/vir.0.81083-0
dc.identifier.eissn1465-2099
dc.identifier.issn0022-1317
dc.identifier.urihttps://doi.org/10.1099/vir.0.81083-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96196
dc.identifier.wosidWOS:000232897400002
dc.language.isoen
dc.pagina.final2947
dc.pagina.inicio2937
dc.revistaJournal of general virology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHantavirus Gc glycoprotein: evidence for a class II fusion protein
dc.typeartículo
dc.volumen86
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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