Reflectance confocal microscopy reduces biopsies in adults and children: A prospective real-life study

Simple item page
dc.catalogadorpva
dc.contributor.authorGonzález Valdés, Sebastián Alejandro
dc.contributor.authorBustos, Sergio
dc.contributor.authorDonoso Mena, Francisca
dc.contributor.authorCaussade, Marie-Chantal
dc.contributor.authorAntúnez Lay, Andrea Carolina
dc.contributor.authorDroppelmann Droppelmann, Katherine Ann
dc.contributor.authorUribe González, Pablo Francisco
dc.contributor.authorPellacani, Giovanni
dc.contributor.authorAbarzúa Araya, Alvaro Rodrigo
dc.contributor.authorNavarrete Dechent, Cristian Patricio
dc.date.accessioned2025-09-25T19:29:47Z
dc.date.available2025-09-25T19:29:47Z
dc.date.issued2025
dc.description.abstractBackground: Reflectance confocal microscopy (RCM) is a non-invasive imaging modality that has been used to evaluate melanocytic and non-melanocytic equivocal lesions and to guide biopsy decisions. Objective: To assess the usefulness of RCM in a real-life clinical setting, evaluate its performance in the pediatric subgroup, and compare the rate of saved biopsies between the general dermatology setting and the skin cancer unit. Methods: This prospective, single-center study was conducted between February 2021 and January 2024, including 1,285 clinically equivocal skin lesions referred for RCM. Diagnosis was recorded and correlated to the gold standard biopsy or clinical follow-up. Results: We obtained an overall 70% RCM-histopathological concordance for specific diagnoses, with higher performance in older patients, head and neck lesions, non-pigmented lesions, and non-melanocytic lesions, particularly basal cell carcinomas. A significant percentage of biopsies were potentially avoided (58.6%), especially in pediatric patients (88.2%). Limitations: Single-center study, not all lesions had histopathological confirmation, and the pediatric group was relatively small. Conclusion: RCM is a valuable diagnostic tool for equivocal skin lesions in real-life practice. It significantly reduces the number of biopsies, thereby enhancing patient care.
dc.format.extent29 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.jaad.2025.09.013
dc.identifier.urihttps://doi.org/10.1016/j.jaad.2025.09.013
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/105773
dc.information.autorucEscuela de Medicina; González Valdés, Sebastián Alejandro; S/I; 1028046
dc.information.autorucEscuela de Medicina; Donoso Mena, Francisca; S/I; 247614
dc.information.autorucEscuela de Medicina; Antúnez Lay, Andrea Carolina; S/I; 187218
dc.information.autorucEscuela de Medicina; Droppelmann Droppelmann, Katherine Ann; S/I; 151172
dc.information.autorucEscuela de Medicina; Uribe González, Pablo Francisco; 0000-0002-3573-2338; 9032
dc.information.autorucEscuela de Medicina; Abarzúa Araya, Alvaro Rodrigo; 0000-0002-7036-0699; 85465
dc.information.autorucEscuela de Medicina; Navarrete Dechent, Cristian Patricio; 0000-0003-4040-3640; 156251
dc.language.isoen
dc.nota.accesocontenido parcial
dc.publisherElsevier Inc.
dc.revistaJournal of the American Academy of Dermatology
dc.rightsacceso restringido
dc.subjectReflectance confocal microscopy
dc.subjectProspective study
dc.subjectNoninvasive diagnosis
dc.subjectSkin cancer
dc.subjectMelanoma
dc.subjectBasal cell carcinoma
dc.subjectSquamous cell carcinoma
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleReflectance confocal microscopy reduces biopsies in adults and children: A prospective real-life study
dc.typepreprint
sipa.codpersvinculados1028046
sipa.codpersvinculados247614
sipa.codpersvinculados187218
sipa.codpersvinculados151172
sipa.codpersvinculados9032
sipa.codpersvinculados85465
sipa.codpersvinculados156251
sipa.trazabilidadORCID;2025-09-22
Files
License bundle
Now showing 1 - 1 of 1
Thumbnail Image
Name:
license.txt
Size:
1.98 KB
Format:
Item-specific license agreed upon to submission
Description:
Download
Collections
Artículos de revistas