Non-Invasive Functional Evaluation of the Human Spinal Cord by Assessing the Peri-Spinal Neurovascular Network With Near Infrared Spectroscopy

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dc.contributor.authorValenzuela, Felipe
dc.contributor.authorRana, Mohit
dc.contributor.authorSitaram, Ranganatha
dc.contributor.authorUribe, Sergio
dc.contributor.authorEblen-Zajjur, Antonio
dc.date.accessioned2025-01-20T22:05:21Z
dc.date.available2025-01-20T22:05:21Z
dc.date.issued2021
dc.description.abstractCurrent medical care lacks an effective functional evaluation for the spinal cord. Magnetic resonance imaging and computed tomography mainly provide structural information of the spinal cord, while spinal somatosensory evoked potentials are limited by a low signal to noise ratio. We developed a non-invasive approach based on near-infrared spectroscopy in dual-wavelength (760 and 850 nm for deoxy- or oxyhemoglobin respectively) to record the neurovascular response (NVR) of the peri-spinal vascular network at the 7th cervical and 10th thoracic vertebral levels of the spinal cord, triggered by unilateral median nerve electrical stimulation (square pulse, 5-10 mA, 5 ms, 1 pulse every 4 minutes) at the wrist. Amplitude, rise-time, and duration of NVR were characterized in 20 healthy participants. A single, painless stimulus was able to elicit a high signal-to-noise ratio and multi-segmental NVR (mainly from Oxyhemoglobin) with a fast rise time of 6.18 [4.4-10.4] seconds (median [Percentile 25-75]) followed by a slow decay phase for about 30 seconds toward the baseline. Cervical NVR was earlier and larger than thoracic and no left/right asymmetry was detected. Stimulus intensity/NVR amplitude fitted to a 2nd order function. The characterization and feasibility of the peri-spinal NVR strongly support the potential clinical applications for a functional assessment of spinal cord lesions.
dc.fuente.origenWOS
dc.identifier.doi10.1109/TNSRE.2021.3123587
dc.identifier.eissn1558-0210
dc.identifier.issn1534-4320
dc.identifier.urihttps://doi.org/10.1109/TNSRE.2021.3123587
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94139
dc.identifier.wosidWOS:000716690000005
dc.language.isoen
dc.pagina.final2321
dc.pagina.inicio2312
dc.revistaIeee transactions on neural systems and rehabilitation engineering
dc.rightsacceso restringido
dc.subjectSpinal cord
dc.subjectMagnetic resonance imaging
dc.subjectSignal to noise ratio
dc.subjectProtocols
dc.subjectOptical filters
dc.subjectSkin
dc.subjectMonitoring
dc.subjectfNIRS
dc.subjectfunctional test
dc.subjectnerve stimulation
dc.subjectneuro-vascular coupling
dc.subjectneuro-vascular response
dc.subjectspinal cord
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNon-Invasive Functional Evaluation of the Human Spinal Cord by Assessing the Peri-Spinal Neurovascular Network With Near Infrared Spectroscopy
dc.typeartículo
dc.volumen29
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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