Nucleophilic Neutralization of Organophosphates: Lack of Selectivity or Plenty of Versatility?

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dc.contributor.authorSilva, Valmir B.
dc.contributor.authorCampos, Renan B.
dc.contributor.authorPavez, Paulina
dc.contributor.authorMedeiros, Michelle
dc.contributor.authorOrth, Elisa S.
dc.date.accessioned2025-01-20T22:19:21Z
dc.date.available2025-01-20T22:19:21Z
dc.date.issued2021
dc.description.abstractNeutralization of organophosphates is an issue of public health and safety, involving agrochemicals and chemical warfare. A promising approach is the nucleophilic neutralization, scope of this review, which focuses on the molecular nucleophiles: hydroxide, imidazole derivatives, alpha nucleophiles, amines and other nucleophiles. A reactivity mapping is given correlating the pathways and reaction efficiency with structural dependence of the nucleophile (basicity) and the organophosphate (electrophilic centers, P=O/P=S shift, leaving and non-leaving group). Reactions extremely unfavorable (>20 years) can be reduced to seconds with various nucleophiles, some which are catalytic. Although there is no universal nucleophile, a lack of selectivity in some cases accounts for plenty of versatility in other reactions. The ideal neutralization requires a solid mechanistic understanding, together with balancing factors such as milder conditions, fast process, selectivity and less toxic products.
dc.fuente.origenWOS
dc.identifier.doi10.1002/tcr.202100123
dc.identifier.eissn1528-0691
dc.identifier.issn1527-8999
dc.identifier.urihttps://doi.org/10.1002/tcr.202100123
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94594
dc.identifier.wosidWOS:000660351800001
dc.issue.numero10
dc.language.isoen
dc.pagina.final2665
dc.pagina.inicio2638
dc.revistaChemical record
dc.rightsacceso restringido
dc.subjectdephosphorylation
dc.subjectphosphate esters
dc.subjectnucleophilic catalysis
dc.subjectorganothiophosphates
dc.subjectorganophosphorus compounds
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNucleophilic Neutralization of Organophosphates: Lack of Selectivity or Plenty of Versatility?
dc.typeartículo
dc.volumen21
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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