Gastric cancer incidence and mortality is associated with altitude in the mountainous regions of Pacific Latin America

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dc.contributor.authorTorres, Javier
dc.contributor.authorCorrea, Pelayo
dc.contributor.authorFerreccio, Catterina
dc.contributor.authorHernandez-Suarez, Gustavo
dc.contributor.authorHerrero, Rolando
dc.contributor.authorCavazza-Porro, Maria
dc.contributor.authorDominguez, Ricardo
dc.contributor.authorMorgan, Douglas
dc.date.accessioned2025-01-24T00:04:51Z
dc.date.available2025-01-24T00:04:51Z
dc.date.issued2013
dc.description.abstractIn Latin America, gastric cancer is a leading cancer, and countries in the region have some of the highest mortality rates worldwide, including Chile, Costa Rica, and Colombia. Geographic variation in mortality rates is observed both between neighboring countries and within nations. We discuss epidemiological observations suggesting an association between altitude and gastric cancer risk in Latin America. In the Americas, the burden of gastric cancer mortality is concentrated in the mountainous areas along the Pacific rim, following the geography of the Andes sierra, from Venezuela to Chile, and the Sierra Madre and Cordillera de Centroam,rica, from southern Mexico to Costa Rica. Altitude is probably a surrogate for host genetic, bacterial, dietary, and environmental factors that may cluster in the mountainous regions. For example, H. pylori strains from patients of the Andean Nario region of Colombia display European ancestral haplotypes, whereas strains from the Pacific coast are predominantly of African origin. The observation of higher gastric cancer rates in the mountainous areas is not universal: the association is absent in Chile, where risk is more strongly associated with the age of H. pylori acquisition and socio-economic determinants. The dramatic global and regional variations in gastric cancer incidence and mortality rates offer the opportunity for scientific discovery and focused prevention programs.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s10552-012-0114-8
dc.identifier.eissn1573-7225
dc.identifier.issn0957-5243
dc.identifier.urihttps://doi.org/10.1007/s10552-012-0114-8
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101818
dc.identifier.wosidWOS:000314063900006
dc.issue.numero2
dc.language.isoen
dc.pagina.final256
dc.pagina.inicio249
dc.revistaCancer causes & control
dc.rightsacceso restringido
dc.subjectGastric cancer
dc.subjectHelicobacter pylori
dc.subjectLatin America
dc.subjectAndean countries
dc.subjectAltitude enigma
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleGastric cancer incidence and mortality is associated with altitude in the mountainous regions of Pacific Latin America
dc.typeartículo
dc.volumen24
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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