Discordant clinical presentation and outcome in infant twins sharing a common clonal leukaemia

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dc.contributor.authorCampbell, M
dc.contributor.authorCabrera, ME
dc.contributor.authorLegues, ME
dc.contributor.authorRidge, S
dc.contributor.authorGreaves, M
dc.date.accessioned2025-01-21T01:34:06Z
dc.date.available2025-01-21T01:34:06Z
dc.date.issued1996
dc.description.abstractWe report the different presentation features and clinical outcome between two identical infant twins with acute lymphoblastic leukaemia with a shared clonal disease and MLL gene rearrangement. One twin relapsed and died, but the other is in complete remission >4 years after diagnosis. These data, and Similar observations on other twin infants with leukaemia, suggest that despite a common clonal in utero, post-natally these leukaemias can evolve independently, at different rates, in the twinned individuals, and that the usually fatal leukaemia associated with t(4;11) MLL gene rearrangement can be effectively treated when the leukaemic burden is small.
dc.fuente.origenWOS
dc.identifier.issn0007-1048
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97514
dc.identifier.wosidWOS:A1996UH21600030
dc.issue.numero1
dc.language.isoen
dc.pagina.final169
dc.pagina.inicio166
dc.revistaBritish journal of haematology
dc.rightsacceso restringido
dc.subjectleukaemia
dc.subjecttwins
dc.subjectMLL gene
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleDiscordant clinical presentation and outcome in infant twins sharing a common clonal leukaemia
dc.typeartículo
dc.volumen93
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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