mRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis

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dc.contributor.authorBlanco, Yolanda
dc.contributor.authorEscudero, Domingo
dc.contributor.authorLleixa, Cinta
dc.contributor.authorLlufriu, Sara
dc.contributor.authorEgri, Natalia
dc.contributor.authorGarcia, Raquel Ruiz
dc.contributor.authorAlba, Mercedes
dc.contributor.authorAguilar, Esther
dc.contributor.authorArtola, Montse
dc.contributor.authorAldea Novo, Marta
dc.contributor.authorAlvarez, Silvia
dc.contributor.authorCaballero, Eva
dc.contributor.authorCabrera-Maqueda, Jose Maria
dc.contributor.authorFonseca, Elianet
dc.contributor.authorGuasp, Mar
dc.contributor.authorHernando, Ana
dc.contributor.authorMartinez-Hernandez, Eugenia
dc.contributor.authorOlive-Cirera, Gemma
dc.contributor.authorLopez-Contreras, Joaquin
dc.contributor.authorMartin-Aguilar, Lorena
dc.contributor.authorMartinez-Martinez, Laura
dc.contributor.authorRombauts, Alexander
dc.contributor.authorRodes, Maria
dc.contributor.authorSabater, Lidia
dc.contributor.authorSepulveda, Maria
dc.contributor.authorSolana, Elisabeth
dc.contributor.authorTejada-Illa, Clara
dc.contributor.authorVidal-Fernandez, Nuria
dc.contributor.authorVilella, Anna
dc.contributor.authorFortuny, Claudia
dc.contributor.authorArmangue, Thais
dc.contributor.authorDalmau, Josep O.
dc.contributor.authorQuerol, Luis
dc.contributor.authorSaiz, Albert
dc.date.accessioned2025-01-20T17:13:00Z
dc.date.available2025-01-20T17:13:00Z
dc.date.issued2023
dc.description.abstractBackground and ObjectiveIn people with multiple sclerosis (pwMS), concern for potential disease exacerbation or triggering of other autoimmune disorders contributes to vaccine hesitancy. We assessed the humoral and T-cell responses to SARS-CoV-2 after mRNA vaccination, changes in disease activity, and development of antibodies against central or peripheral nervous system antigens.MethodsThis was a prospective 1-year longitudinal observational study of pwMS and a control group of patients with other inflammatory neurologic disorders (OIND) who received an mRNA vaccine. Blood samples were obtained before the first dose (T1), 1 month after the first dose (T2), 1 month after the second dose (T3), and 6 (T4), 9 (T5), and 12 (T6) months after the first dose. Patients were assessed for the immune-specific response, annualized relapse rate (ARR), and antibodies to onconeuronal, neural surface, glial, ganglioside, and nodo-paranodal antigens.ResultsAmong 454 patients studied, 390 had MS (22 adolescents) and 64 OIND; the mean (SD) age was 44 (14) years; 315 (69%) were female; and 392 (87%) were on disease-modifying therapies. Antibodies to the receptor-binding domain were detected in 367 (86%) patients at T3 and 276 (83%) at T4. After a third dose, only 13 (22%) of 60 seronegative patients seroconverted, and 255 (92%) remained seropositive at T6. Cellular responses were present in 381 (93%) patients at T3 and in 235 (91%) patients at T6 including all those receiving anti-CD20 therapies and in 79% of patients receiving fingolimod. At T3 (429 patients) or T6 (395 patients), none of the patients had developed CNS autoantibodies. Seven patients had neural antibodies that were already present before immunization (3 adult patients with MS had MOG-IgG, 2 with MG and 1 with MS had neuronal cell surface antibodies [unknown antigen], and 1 with MS had myelin antibody reactivity [unknown antigen]. Similarly, no antibodies against PNS antigens were identified at T3 (427 patients). ARR was lower in MS and not significantly different in patients with OIND. Although 182 (40%) patients developed SARS-CoV-2 infection, no cases of severe COVID-19 or serious adverse events occurred.DiscussionIn this study, mRNA COVID-19 vaccination was safe and did not exacerbate the autoimmune disease nor triggered neural autoantibodies or immune-mediated neurologic disorders. The outcome of patients who developed SARS-CoV-2 infection was favorable.
dc.fuente.origenWOS
dc.identifier.doi10.1212/NXI.0000000000200163
dc.identifier.issn2332-7812
dc.identifier.urihttps://doi.org/10.1212/NXI.0000000000200163
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/91264
dc.identifier.wosidWOS:001290521700001
dc.issue.numero6
dc.language.isoen
dc.revistaNeurology-neuroimmunology & neuroinflammation
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titlemRNA COVID-19 Vaccination Does Not Exacerbate Symptoms or Trigger Neural Antibody Responses in Multiple Sclerosis
dc.typeartículo
dc.volumen10
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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