Network pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19

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dc.contributor.authorAlegria-Arcos, Melissa
dc.contributor.authorBarbosa, Tabata
dc.contributor.authorSepulveda, Felipe
dc.contributor.authorCombariza, German
dc.contributor.authorGonzalez, Janneth
dc.contributor.authorGil, Carmen
dc.contributor.authorMartinez, Ana
dc.contributor.authorRamirez, David
dc.date.accessioned2025-01-20T21:02:50Z
dc.date.available2025-01-20T21:02:50Z
dc.date.issued2022
dc.description.abstractThe coronavirus disease 2019 pandemic accelerated drug/vaccine development processes, integrating scientists all over the globe to create therapeutic alternatives against this virus. In this work, we have collected information regarding proteins from SARS-CoV-2 and humans and how these proteins interact. We have also collected information from public databases on protein-drug interactions. We represent this data as networks that allow us to gain insights into protein-protein interactions between both organisms. With the collected data, we have obtained statistical metrics of the networks. This data analysis has allowed us to find relevant information on which proteins and drugs are the most relevant from the network pharmacology perspective. This method not only allows us to focus on viral proteins as the main targets for COVID-19 but also reveals that some human proteins could be also important in drug repurposing campaigns. As a result of the analysis of the SARS-CoV-2-human interactome, we have identified some old drugs, such as disulfiram, auranofin, gefitinib, suloctidil, and bromhexine as potential therapies for the treatment of COVID-19 deciphering their potential complex mechanism of action.
dc.fuente.origenWOS
dc.identifier.doi10.3389/fphar.2022.952192
dc.identifier.eissn1663-9812
dc.identifier.urihttps://doi.org/10.3389/fphar.2022.952192
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/93090
dc.identifier.wosidWOS:000848349900001
dc.language.isoen
dc.revistaFrontiers in pharmacology
dc.rightsacceso restringido
dc.subjectprotein-protein interaction network
dc.subjectprotein-drug interaction network
dc.subjectdrug repurposing
dc.subjectSARS-CoV-2
dc.subjectCOVID-19
dc.subjectnetwork pharmacology
dc.subjectpolypharmacology
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNetwork pharmacology reveals multitarget mechanism of action of drugs to be repurposed for COVID-19
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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