A stable nanosilver decorated phosphorene nanozyme with phosphorus- doped porous carbon microsphere for intelligent sensing of 8-hydroxy-20-deoxyguanosine

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dc.contributor.authorSheng, Yingying
dc.contributor.authorZhu, Yifu
dc.contributor.authorCeron, Maria Luisa
dc.contributor.authorYi, Yufu
dc.contributor.authorLiu, Peng
dc.contributor.authorWang, Peng
dc.contributor.authorXue, Ting
dc.contributor.authorCamarada, Maria Belen
dc.contributor.authorWen, Yangping
dc.date.accessioned2025-01-20T22:11:49Z
dc.date.available2025-01-20T22:11:49Z
dc.date.issued2021
dc.description.abstractNanozyme based on the silver nanoparticles (AgNPs) decorated highly water-oxygen stable phosphorene (BP) nanohybrid with phosphorus-doped porous carbon microspheres (P-PCMs) is applied as an intelligent sensing platform for the electrochemical detection of 8-hydroxy-20-deoxyguanosine (8-OHdG) as a biomarker of oxidative DNA damage in human urine sample. The density functional theory (DFT) is use for investigating the effect of silver on the conductivity level of BP and discussing a possible mechanism for the electrocatalytic oxidation of 8-OHdG. The Ag+ is in-situ reduced as AgNPs that grows onto the BP surface for the controllable preparation of BP-AgNPs with effective surface passivation among different metal ions decorated BP. P-PCMs with 4.9-fold enhancement in specific surface area (1636.73 m2 g-1) are prepared by hydrothermal carbonization of alpha cyclodextrin as carbon sources, then calcinate in the presence of phosphoric acid as an activator and dopant. P-PCMs-BP-AgNPs are prepared by the ultrasound-assisted liquid-phase exfoliation with the addition of Ag+, and both P-PCMs and black phosphorus crystals are sufficiently grinded. The P-PCMs-BP-AgNPs nanohybrid displays good long-term water-oxygen stability, extraordinary specific surface area, superior electrocatalytic capacity with 303-fold enhancement, enzyme-like characteristics with Imax of 100 mu A and Km of 29 mu M. The machine learning (ML) model with artificial neural network (ANN) algorithm is employed for the intelligent output of 8-OHdG in real sample with acceptable recovery in work range from 0.2 to 125 mu M.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jelechem.2021.115522
dc.identifier.eissn1873-2569
dc.identifier.issn1572-6657
dc.identifier.urihttps://doi.org/10.1016/j.jelechem.2021.115522
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94416
dc.identifier.wosidWOS:000681679500004
dc.language.isoen
dc.revistaJournal of electroanalytical chemistry
dc.rightsacceso restringido
dc.subjectPhosphorene
dc.subjectPorous carbon
dc.subjectNanozyme
dc.subjectMachine learning
dc.subjectElectrochemical sensor
dc.subjectWater-oxygen stability
dc.titleA stable nanosilver decorated phosphorene nanozyme with phosphorus- doped porous carbon microsphere for intelligent sensing of 8-hydroxy-20-deoxyguanosine
dc.typeartículo
dc.volumen895
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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