Functionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring

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dc.contributor.authorDonoso-Gonzalez, Orlando
dc.contributor.authorLodeiro, Lucas
dc.contributor.authorAliaga, Alvaro E.
dc.contributor.authorLaguna-Bercero, Miguel A.
dc.contributor.authorBollo, Soledad
dc.contributor.authorKogan, Marcelo J.
dc.contributor.authorYutronic, Nicolas
dc.contributor.authorSierpe, Rodrigo
dc.date.accessioned2025-01-20T23:53:16Z
dc.date.available2025-01-20T23:53:16Z
dc.date.issued2021
dc.description.abstractGold nanostars (AuNSs) exhibit modulated plasmon resonance and have a high SERS enhancement factor. However, their low colloidal stability limits their biomedical application as a nanomaterial. Cationic beta-cyclodextrin-based polymer (CCD/P) has low cytotoxicity, can load and transport drugs more efficiently than the corresponding monomeric form, and has an appropriate cationic group to stabilize gold nanoparticles. In this work, we functionalized AuNSs with CCD/P to load phenylethylamine (PhEA) and piperine (PIP) and evaluated SERS-based applications of the products. PhEA and PIP were included in the polymer and used to functionalize AuNSs, forming a new AuNS-CCD/P-PhEA-PIP nanosystem. The system was characterized by UV-VIS, IR, and NMR spectroscopy, TGA, SPR, DLS, zeta potential analysis, FE-SEM, and TEM. Additionally, Raman optical activity, SERS analysis and complementary theoretical studies were used for characterization. Minor adjustments increased the colloidal stability of AuNSs. The loading capacity of the CCD/P with PhEA-PIP was 95 +/- 7%. The physicochemical parameters of the AuNS-CCD/P-PhEA-PIP system, such as size and Z potential, are suitable for potential biomedical applications Raman and SERS studies were used to monitor PhEA and PIP loading and their preferential orientation upon interaction with the surface of AuNSs. This unique nanomaterial could be used for simultaneous drug loading and SERS-based detection.
dc.fuente.origenWOS
dc.identifier.doi10.3390/pharmaceutics13020261
dc.identifier.eissn1999-4923
dc.identifier.urihttps://doi.org/10.3390/pharmaceutics13020261
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/94949
dc.identifier.wosidWOS:000623005800001
dc.issue.numero2
dc.language.isoen
dc.revistaPharmaceutics
dc.rightsacceso restringido
dc.subjectgold nanostars
dc.subjectcationic &#946
dc.subject-cyclodextrin-based polymer
dc.subjectphenylethylamine
dc.subjectpiperine
dc.subjectdrug co-loading
dc.subjectsurface-enhanced Raman scattering
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleFunctionalization of Gold Nanostars with Cationic β-Cyclodextrin-Based Polymer for Drug Co-Loading and SERS Monitoring
dc.typeartículo
dc.volumen13
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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