Niemann-Pick C2 Protein Expression Regulates Lithogenic Diet-Induced Gallstone Formation and Dietary Cholesterol Metabolism in Mice

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dc.contributor.authorBalboa, Elisa
dc.contributor.authorMorales, Gabriela
dc.contributor.authorAylwin, Paula
dc.contributor.authorCarrasco, Gonzalo
dc.contributor.authorAmigo, Ludwig
dc.contributor.authorCastro, Juan
dc.contributor.authorRigotti, Attilio
dc.contributor.authorZanlungo, Silvana
dc.date.accessioned2024-01-10T12:06:56Z
dc.date.available2024-01-10T12:06:56Z
dc.date.issued2012
dc.description.abstractNiemann-Pick C2 protein (NPC2) is a lysosomal soluble protein that is highly expressed in the liver; it binds to cholesterol and is involved in intracellular cholesterol trafficking, allowing the exit of lysosomal cholesterol obtained via the lipoprotein endocytic pathway. Thus, this protein may play an important role in controlling hepatic cholesterol transport and metabolism. The aim of this work was to study the relevance of NPC2 protein expression in hepatic cholesterol metabolism, biliary lipid secretion and gallstone formation by comparing NPC2 hypomorph [NPC2 (h/h)] and wild-type mice fed control, 2% cholesterol, and lithogenic diets. NPC2 (h/h) mice exhibited resistance to a diet-induced increase in plasma cholesterol levels. When consuming the chow diet, we observed increased biliary cholesterol and phospholipid secretions in NPC2 (h/h) mice. When fed the 2% cholesterol diet, NPC2 (h/h) mice exhibited low and high gallbladder bile cholesterol and phospholipid concentrations, respectively. NPC2 (h/h) mice fed with the lithogenic diet showed reduced biliary cholesterol secretion, gallbladder bile cholesterol saturation, and cholesterol crystal and gallstone formation. This work indicates that hepatic NPC2 expression is an important factor in the regulation of diet-derived cholesterol metabolism and disposal as well as in diet-induced cholesterol gallstone formation in mice.
dc.description.funderFondo Nacional de Desarrollo Cientifico y Tecnologico (FONDECYT)
dc.description.funderFONDAP
dc.description.funderDireccion de Investigacion, Facultad de Medicina, UC
dc.fechaingreso.objetodigital2024-03-14
dc.format.extent13 páginas
dc.fuente.origenWOS
dc.identifier.doi10.1007/s11745-011-3625-2
dc.identifier.issn0024-4201
dc.identifier.pubmedidMEDLINE:22038687
dc.identifier.urihttps://doi.org/10.1007/s11745-011-3625-2
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/76224
dc.identifier.wosidWOS:000299532400002
dc.information.autorucMedicina;Amigo L ;S/I;62028
dc.information.autorucMedicina;Aylwin P;S/I;179224
dc.information.autorucMedicina;Balboa E ;S/I;142402
dc.information.autorucMedicina;Carrasco G ;S/I;14818
dc.information.autorucMedicina;Castro J ;S/I;8518
dc.information.autorucMedicina;Morales G ;S/I;204746
dc.information.autorucMedicina;Rigotti A;S/I;68489
dc.information.autorucMedicina;Zanlungo S ;S/I;72650
dc.issue.numero1
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final25
dc.pagina.inicio13
dc.publisherSPRINGER HEIDELBERG
dc.revistaLIPIDS
dc.rightsacceso restringido
dc.subjectNiemann-Pick type C2 protein
dc.subjectCholesterol
dc.subjectLiver
dc.subjectBiliary lipid secretion
dc.subjectGallstone disease
dc.subjectGallbladder
dc.subjectPHOSPHATIDYLCHOLINE TRANSFER PROTEIN
dc.subjectBILIARY LIPID SECRETION
dc.subjectDEFICIENT MICE
dc.subjectSTEROL BINDING
dc.subjectNPC2 PROTEIN
dc.subjectDISEASE
dc.subjectC1
dc.subjectHOMEOSTASIS
dc.subjectBILE
dc.subjectDENSITY
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleNiemann-Pick C2 Protein Expression Regulates Lithogenic Diet-Induced Gallstone Formation and Dietary Cholesterol Metabolism in Mice
dc.typeartículo
dc.volumen47
sipa.codpersvinculados62028
sipa.codpersvinculados179224
sipa.codpersvinculados142402
sipa.codpersvinculados14818
sipa.codpersvinculados8518
sipa.codpersvinculados204746
sipa.codpersvinculados68489
sipa.codpersvinculados72650
sipa.indexWOS
sipa.indexScopus
sipa.trazabilidadCarga SIPA;09-01-2024
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