Role of Peripheral Chemoreceptors on Enhanced Central Chemoreflex Drive in Nonischemic Heart Failure

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dc.article.number1164357
dc.contributor.authorPereyra K.
dc.contributor.authorDiaz-Jara E.
dc.contributor.authorArias P.
dc.contributor.authorBravo L.
dc.contributor.authorToledo C.
dc.contributor.authorSchwarz K.
dc.contributor.authorDel Rio R.
dc.contributor.otherCEDEUS (Chile)
dc.date.accessioned2025-05-01T10:33:07Z
dc.date.available2025-05-01T10:33:07Z
dc.date.issued2023
dc.description.abstract© 2023. The Author(s), under exclusive license to Springer Nature Switzerland AG.Heart failure (HF) is a prevalent disease in elderly population. Potentiation of the ventilatory chemoreflex drive plays a pivotal role in disease progression, at least in part, through their contribution to the generation/maintenance of breathing disorders. Peripheral and central chemoreflexes are mainly regulated by carotid body (CB) and the retrotrapezoid nuclei (RTN), respectively. Recent evidence showed an enhanced central chemoreflex drive in rats with nonischemic HF along with breathing disorders. Importantly, increase activity from RTN chemoreceptors contribute to the potentiation of central chemoreflex response to hypercapnia. The precise mechanism driving RTN potentiation in HF is still elusive. Since interdependency of RTN and CB chemoreceptors has been described, we hypothesized that CB afferent activity is required to increase RTN chemosensitivity in the setting of HF. Accordingly, we studied central/peripheral chemoreflex drive and breathing disorders in HF rats with and without functional CBs (CB denervation). We found that CB afferent activity was required to increase central chemoreflex drive in HF. Indeed, CB denervation restored normal central chemoreflex drive and reduced the incidence of apneas by twofold. Our results support the notion that CB afferent activity plays an important role in central chemoreflex potentiation in rats with HF.
dc.description.funderNational Agency for Research and Development
dc.description.funderFondecyt
dc.description.funderANID
dc.format.extent11 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1007/978-3-031-32371-3_12
dc.identifier.eisbn9780128194706
dc.identifier.eissn1549-7828
dc.identifier.isbn9783031764011
dc.identifier.issn00652598
dc.identifier.pubmedid40156360
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85163268270
dc.identifier.urihttps://doi.org/10.1007/978-3-031-32371-3_12
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103954
dc.identifier.wosidWOS:001159473800013
dc.information.autorucFacultad de Ciencias Biológicas; Del Rio Troncoso Rodrigo Andre; 0000-0003-0315-6660; 126608
dc.issue.numero2
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final114
dc.pagina.inicio107
dc.publisherSpringer
dc.relation.ispartofIntersections Interdisciplinary Research on Architecture, Design, City and Territory
dc.revistaAdvances in experimental medicine and biology
dc.rightsacceso restringido
dc.subjectCarotid body denervation
dc.subjectCentral chemoreflex potentiation
dc.subjectHeart failure
dc.subjectRTN
dc.subject.ddc620
dc.subject.deweyIngenieríaes_ES
dc.subject.ods11 Sustainable cities and communities
dc.subject.odspa11 Ciudades y comunidades sostenibles
dc.titleRole of Peripheral Chemoreceptors on Enhanced Central Chemoreflex Drive in Nonischemic Heart Failure
dc.typeartículo
dc.volumen1427
sipa.codpersvinculados126608
sipa.indexScopus
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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