Cervical metastases of glucagonoma in a patient with multiple endocrine neoplasia type 1: Report of a case

Simple item page
dc.contributor.authorButte, Jean M.
dc.contributor.authorMontero, Pablo H.
dc.contributor.authorSolar, Antonieta
dc.contributor.authorTorres, Javiera
dc.contributor.authorOlmos, Pablo R.
dc.contributor.authorGoni, Ignacio
dc.contributor.authorQuintana, Juan C.
dc.contributor.authorMartinez, Jorge
dc.contributor.authorLlanos, Osvaldo
dc.date.accessioned2025-01-21T01:04:56Z
dc.date.available2025-01-21T01:04:56Z
dc.date.issued2008
dc.description.abstractMultiple endocrine neoplasia type 1 (MEN 1) is a syndrome characterized by tumors of the parathyroid glands, pancreatic islet cells, duodenum, and pituitary gland. We report a case of cervical metastases of glucagonoma with MEN 1. The patient was a 34-year-old woman admitted to our hospital with epigastric pain. Her medical history included two resections of prolactinoma and two upper GI hemorrhages secondary to duodenal ulcers. Computed tomography (CT) showed two hypervascular lesions in the tail of the pancreas and cervical ultrasound showed multiple hypoechogenic ovoid images in the neck. A cervical CT scan confirmed two 15-mm lymph nodes in the left cervical region and 111In-DOTATOC imaging showed focal abnormal somatostatin expression in the pancreatic tail and the cervical nodes. The patient had asymptomatic hypoglycemic episodes, with blood sugar levels as low as 30 mg/dl, which raised our suspicion of MEN 1 associated with pancreatic insulinoma. Thus, we performed a distal pancreatectomy with bilateral cervical dissection and parathyroid gland resection. Histopathological examination revealed 12 pancreatic tumors as well as metastases in four cervical lymph nodes. The resected parathyroid glands had normal structure, suggesting parathyroid hyperplasia. A follow-up CT scan, 18 months after surgery, showed new tumors in the head of the pancreas and in the duodenal wall. A pancreatoduodenectomy was performed and histopathological examination revealed nine nonfunctioning endocrine tumors in the pancreas, one tumor in the duodenal wall, and metastases in two peripancreatic lymph nodes. The patient recovered well and remains asymptomatic.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s00595-008-3763-1
dc.identifier.issn0941-1291
dc.identifier.urihttps://doi.org/10.1007/s00595-008-3763-1
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95744
dc.identifier.wosidWOS:000261264700014
dc.issue.numero12
dc.language.isoen
dc.pagina.final1143
dc.pagina.inicio1137
dc.revistaSurgery today
dc.rightsacceso restringido
dc.subjectMultiple endocrine neoplasia type 1
dc.subjectGlucagonoma
dc.subjectCervical metastases
dc.subjectSurgical treatment
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCervical metastases of glucagonoma in a patient with multiple endocrine neoplasia type 1: Report of a case
dc.typeartículo
dc.volumen38
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
Files
Collections
Artículos de revistas