Right ventricular function in patients with pulmonary regurgitation with versus without tetralogy of Fallot

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dc.contributor.authorLarios, Guillermo
dc.contributor.authorYim, Deane
dc.contributor.authorDragulescu, Andreea
dc.contributor.authorMertens, Luc
dc.contributor.authorGrosse-Wortmann, Lars
dc.contributor.authorFriedberg, Mark K.
dc.date.accessioned2025-01-23T21:12:39Z
dc.date.available2025-01-23T21:12:39Z
dc.date.issued2019
dc.description.abstractBackground Right ventricular (RV) dilation from pulmonary valve regurgitation (PR) is common after intervention(s) for pulmonary stenosis (PS) or atresia and intact ventricular septum (PA/IVS). It is not well established whether PR and RV dilation have similar effects on RV function and exercise capacity in these patients compared to patients after repair of tetralogy of Fallot (rToF). The aims of this study were to compare exercise tolerance, RV function and myocardial mechanics in non-ToF versus rToF children with significantly increased and comparable RV volumes.
dc.description.abstractMethods Thirty PS or PA/IVS children after intervention(s) with significant PR and RV dilation (non-ToF group) were retrospectively matched for RV end-diastolic volume index (RVEDVi) and age with 30 rToF patients. Clinical characteristics, RV function by echocardiography and CMR, ECG and exercise capacity were compared between groups.
dc.description.abstractResults The groups were well matched for RVEDVi and age. Global RV function (RVEF: 48.7 +/- 6.4% vs. 48.5 +/- 7.2%, P = .81) and exercise capacity (% predicted peak VO2:82.5 +/- 17.7% vs. 75.6 +/- 20.4%, P = .27) were similarly reduced between groups. RVEDVi correlated inversely with RVEF in both groups (non-ToF: r = -0.39, P = .04, rToF: r = -0.40, P = .03). QRS duration was wider in rToF patients, and in both groups inversely correlated with RVEF (non-ToF: r = -0.77, P < .001, rToF: r = -0.69, P < .001). In contrast to global function, longitudinal RV strain was lower in rTOF vs non-TOF (-20.1 +/- 3.9 vs. -25.7 +/- 4.4, P < .001).
dc.description.abstractConclusions Global RV function and exercise capacity are similarly reduced in non-ToF and rToF patients with severely dilated RV, after matching by RVEDVi, suggesting a comparable impact of RV dilation on RV global function. The significance of reduced RV longitudinal function and worse dyssynchrony in rToF patients require further exploration.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.ahj.2019.03.012
dc.identifier.eissn1097-6744
dc.identifier.issn0002-8703
dc.identifier.urihttps://doi.org/10.1016/j.ahj.2019.03.012
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100966
dc.identifier.wosidWOS:000471598600002
dc.language.isoen
dc.pagina.final17
dc.pagina.inicio8
dc.revistaAmerican heart journal
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRight ventricular function in patients with pulmonary regurgitation with versus without tetralogy of Fallot
dc.typeartículo
dc.volumen213
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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