Evaluation of mismatch negativity as a marker for language impairment in autism spectrum disorder

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dc.contributor.authorGreen, Heather L.
dc.contributor.authorShuffrey, Lauren C.
dc.contributor.authorLevinson, Lisa
dc.contributor.authorShen, Guannan
dc.contributor.authorAvery, Trey
dc.contributor.authorWagner, Melissa Randazzo
dc.contributor.authorSepulveda, Dayna Moya
dc.contributor.authorGarcia, Paula
dc.contributor.authorMaddox, Chaille
dc.contributor.authorGarcia, Felicidad
dc.contributor.authorHassan, Sommer
dc.contributor.authorFroud, Karen
dc.date.accessioned2025-01-23T19:47:49Z
dc.date.available2025-01-23T19:47:49Z
dc.date.issued2020
dc.description.abstractBackground: The identification of an early and objective marker of language impairment in autism spectrum disorder (ASD) has the potential to lead to earlier language intervention for affected children. The mismatch negativity (MMN), a passive auditory evoked potential, offers insight into the brain's ability to direct attention to novel sounds. Since exposure to speech is necessary for learning to map meaning onto phonemes, we predicted slower MMN responses to speech sounds would indicate presence of language impairment in ASD.
dc.description.abstractMethods: We explored the relationship between MMN latency in children ages 5-10 with ASD plus language impairment (ASD + LI), ASD minus language impairment (ASD-LI), and typically developing children (TD) during an auditory oddball experiment presenting speech and pure tone sounds.
dc.description.abstractResults: Contrary to our prediction, children with ASD + LI demonstrated decreased MMN latency in the left hemisphere in response to novel vowel sounds compared to children with ASD-LI and TD controls. Parent responses to the Sensory Experiences Questionnaire revealed that all participating individuals with ASD were hypersensitive to sounds.
dc.description.abstractConclusions: Our results lend support to the theory that some children with ASD + LI have increased connectivity in primary sensory cortices at the expense of connectivity to association areas of the brain. This may account for faster speech sound processing despite low language scores in these children. Future studies should focus on individuals with language impairment and hyper-or hyposensitivity to sounds.
dc.fuente.origenWOS
dc.identifier.doi10.1016/j.jcomdis.2020.105997
dc.identifier.eissn1873-7994
dc.identifier.issn0021-9924
dc.identifier.urihttps://doi.org/10.1016/j.jcomdis.2020.105997
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/100412
dc.identifier.wosidWOS:000575152300015
dc.language.isoen
dc.revistaJournal of communication disorders
dc.rightsacceso restringido
dc.subjectASD
dc.subjectLanguage
dc.subjectElectroencephalography
dc.subjectElectrophysiology
dc.subjectMismatch negativity
dc.subjectBiomarker
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEvaluation of mismatch negativity as a marker for language impairment in autism spectrum disorder
dc.typeartículo
dc.volumen87
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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