STRESS HYPERGLYCEMIC RESPONSE AFTER CENTRAL AND PERIPHERAL MONO-AMINERGIC NEURONS DESTRUCTION, OR ADRENAL CATECHOLAMINES DEPRIVATION

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dc.contributor.authorROMERO, G
dc.contributor.authorVALDES, EM
dc.contributor.authorYANEZ, MT
dc.contributor.authorKAWADA, ME
dc.contributor.authorVARGAS, L
dc.date.accessioned2025-01-23T19:44:03Z
dc.date.available2025-01-23T19:44:03Z
dc.date.issued1982
dc.description.abstractRestraint stress of 60 min in unfasted non-diabetic 80%-pancreatectomized rats produced a stress diabetic response with significant glycosuria and hyperglycemia. This model was used to investigate the influence of central noradrenergic, dopaminergic, serotoninergic and peripheral noradrenergic neurons, by means of selective chemical lesion. 6-Hydroxydopamine (6-OH-DA) was used to damage noradrenergic and dopaminergic neurons and 5,6-dihydroxytryptamine for serotoninergic neurons. The sympatho-adrenal system was also studied by adrenal demedullation. Results showed that intracerebro-ventricular administration of 6-OH-DA alone, or followed by 5,6-dihydroxytryptamine, had no influence on the stress hyperglycemic response. Central and peripheral 6-OH-DA administration to intact new born rats did not modify the stress response at the adult age. The hypothalamic monoaminergic and neighboring neurons appear to have no influence in the mechanism of stress hyperglycemia. The pseudo-aggressive behavior which arose after central noradrenergic and dopaminergic lesion, returned to normal after serotoninergic neuron destruction. Bilateral adrenal-medullectomy abolished the stress hyperglycemia. Adrenal catecholamines were necessary for the production of restraint stress hyperglycemia. Among these catecholamines, adrenaline [epinephrine] is proposed as the trigger factor.
dc.fuente.origenWOS
dc.identifier.issn0004-0533
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99924
dc.identifier.wosidWOS:A1982PY94500018
dc.issue.numero3-4
dc.language.isoen
dc.pagina.final345
dc.pagina.inicio339
dc.revistaArchivos de biologia y medicina experimentales
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleSTRESS HYPERGLYCEMIC RESPONSE AFTER CENTRAL AND PERIPHERAL MONO-AMINERGIC NEURONS DESTRUCTION, OR ADRENAL CATECHOLAMINES DEPRIVATION
dc.typeartículo
dc.volumen15
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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