BLOCKADE OF DOPAMINE-INDUCED CHEMOSENSORY INHIBITION BY DOMPERIDONE

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dc.contributor.authorZAPATA, P
dc.contributor.authorTORREALBA, F
dc.date.accessioned2025-01-23T19:43:44Z
dc.date.available2025-01-23T19:43:44Z
dc.date.issued1984
dc.description.abstractThe sensory discharges from the carotid body chemoreceptors of the cat are transiently inhibited by dopamine (DA) injections. This chemosensory inhibition was effectively blocked by domperidone, a selective antagonist of D2 dopaminoceptors. The basal frequency of spontaneous chemosensory impulses was immediately and sustainly increased after domperidone, suggesting the withdrawal of a tonic inhibition of chemosensory discharges by endogenous DA released from glomus cells. The peripheral dopaminergic modulation of chemoreflexes may be separately blocked by domperidone, a drug unable to cross the blood-brain barrier.
dc.fuente.origenWOS
dc.identifier.eissn1872-7972
dc.identifier.issn0304-3940
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99789
dc.identifier.wosidWOS:A1984TX14000012
dc.issue.numero3
dc.language.isoen
dc.pagina.final364
dc.pagina.inicio359
dc.revistaNeuroscience letters
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleBLOCKADE OF DOPAMINE-INDUCED CHEMOSENSORY INHIBITION BY DOMPERIDONE
dc.typeartículo
dc.volumen51
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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