How are mitochondrial nucleoids trafficked?

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dc.article.number877209
dc.contributor.authorMacuada Alvarado, Josefa Pilar
dc.contributor.authorMolina Riquelme, Isidora Elvira
dc.contributor.authorEisner, Verónica
dc.date.accessioned2025-05-01T10:32:42Z
dc.date.available2025-05-01T10:32:42Z
dc.date.issued2025
dc.description.abstractMitochondria harbor their own DNA (mtDNA), which codifies essential proteins of the oxidative phosphorylation (OXPHOS) system and locally feeds them to their surrounding inner mitochondrial membrane (IMM), according to the ‘sphere of influence’ theory. mtDNA is compacted into nucleoids, which are tethered to the IMM and distributed throughout the mitochondrial network. Some nucleoid subpopulations present distinct intramitochondrial positioning during fission and their correct positioning is associated with mtDNA segregation and selective degradation. This opinion article focuses on different mechanisms that could control nucleoid positioning through intramitochondrial trafficking, either by cristae reshaping or by intercompartment-driven mechanisms involving the mitochondrial membranes and extramitochondrial elements. Understanding nucleoid trafficking promises insights into mitochondrial dysfunction in pathologies with mtDNA distribution and segregation issues.
dc.description.funderAgencia Nacional de Investigación y Desarrollo
dc.description.funderFONDECYT
dc.format.extent11 páginas
dc.fuente.origenScopus
dc.identifier.doi10.1016/j.tcb.2024.12.007
dc.identifier.eisbn9781665444347
dc.identifier.eissn1879-3088
dc.identifier.isbn978-1-0716-1533-1
dc.identifier.issn0962- 8924
dc.identifier.pubmedid39984359
dc.identifier.scieloidS0718-69242020000300109
dc.identifier.scopusidSCOPUS_ID:85218825185
dc.identifier.urihttps://doi.org/10.1016/j.tcb.2024.12.007
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/103888
dc.identifier.wosidWOS:001441754200001
dc.information.autorucFacultad de Ciencias Biológicas; Macuada Alvarado, Josefa Pilar; 0000-0001-7310-2233; 247431
dc.information.autorucFacultad de Ciencias Biológicas; Molina Riquelme, Isidora Elvira; 0000-0002-0229-8512; 1126907
dc.issue.numero3
dc.language.isoen
dc.nota.accesoContenido parcial
dc.pagina.final204
dc.pagina.inicio194
dc.publisherHUMANA PRESS INC
dc.relation.ispartofIEEE Global Engineering Education Conference, EDUCON
dc.revistaTrends in Cell Biology
dc.rightsacceso restringido
dc.subjectCristae reshaping
dc.subjectMitochondrial nucleoid
dc.subjectmtDNA inheritance
dc.subjectNucleoid dynamics
dc.subjectSphere of influence
dc.subject.ddc610
dc.subject.deweyMedicina y saludes_ES
dc.subject.ods03 Good health and well-being
dc.subject.odspa03 Salud y bienestar
dc.titleHow are mitochondrial nucleoids trafficked?
dc.typeartículo
dc.volumen35
sipa.codpersvinculados247431
sipa.codpersvinculados1126907
sipa.indexScopus
sipa.indexPubmed
sipa.indexWOS
sipa.trazabilidadCarga WOS-SCOPUS;01-05-2025
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