Evolutionary potentials: structure specific knowledge-based potentials exploiting the evolutionary record of sequence homologs

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dc.article.numberR68
dc.catalogadoraba
dc.contributor.authorPanjkovich, A.
dc.contributor.authorMelo Ledermann, Francisco Javier
dc.contributor.authorMarti Renom, M. A.
dc.date.accessioned2025-02-05T19:50:38Z
dc.date.available2025-02-05T19:50:38Z
dc.date.issued2008
dc.description.abstractWe introduce a new type of knowledge-based potentials for protein structure prediction, called 'evolutionary potentials', which are derived using a single experimental protein structure and all three-dimensional models of its homologous sequences. The new potentials have been benchmarked against other knowledge-based potentials, resulting in a significant increase in accuracy for model assessment. In contrast to standard knowledge-based potentials, we propose that evolutionary potentials capture key determinants of thermodynamic stability and specific sequence constraints required for fast folding.
dc.fuente.origenSIPA
dc.identifier.doi10.1186/gb-2008-9-4-r68
dc.identifier.eissn1465-6914
dc.identifier.issn1465-6906
dc.identifier.pubmedid18397517
dc.identifier.pubmedidPMC2643939
dc.identifier.scopusid2-s2.0-47149093202
dc.identifier.urihttps://doi.org/10.1186/gb-2008-9-4-r68
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102161
dc.identifier.wosidWOS:000256574800012
dc.information.autorucFacultad de Ciencias Biológicas; Melo Ledermann, Francisco Javier; 0000-0002-0424-5991; 82342
dc.language.isoen
dc.nota.accesocontenido completo
dc.pagina.final11
dc.pagina.inicio1
dc.revistaGenome biology
dc.rightsacceso abierto
dc.rights.licenseAttribution 2.0 Generic
dc.rights.urihttps://creativecommons.org/licenses/by/2.0/
dc.subject.ddc570
dc.subject.deweyBiología
dc.titleEvolutionary potentials: structure specific knowledge-based potentials exploiting the evolutionary record of sequence homologs
dc.typeartículo
dc.volumen9
sipa.codpersvinculados82342
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