The LINC complex in blood vessels: from physiology to pathological implications in arterioles

Simple item page
dc.catalogadorjwg
dc.contributor.authorFerreira G.
dc.contributor.authorCardozo R.
dc.contributor.authorChavarria L.
dc.contributor.authorSantander A.
dc.contributor.authorSobrevia Luarte, Luis Alberto
dc.contributor.authorChang W.
dc.contributor.authorGundersen G.
dc.contributor.authorNicolson G.L.
dc.date.accessioned2025-03-18T18:54:32Z
dc.date.available2025-03-18T18:54:32Z
dc.date.issued2025
dc.description.abstract© 2025 The Authors. The Journal of Physiology © 2025 The Physiological Society.The LINC (linker of nucleoskeleton and cytoskeleton) complex is a critical component of the cellular architecture that bridges the nucleoskeleton and cytoskeleton and mediates mechanotransduction to and from the nucleus. Though it plays important roles in all blood vessels, it is in arterioles that this complex plays a pivotal role in maintaining endothelial cell integrity, regulating vascular tone, forming new microvessels and modulating responses to mechanical and biochemical stimuli. It is also important in vascular smooth muscle cells and fibroblasts, where it possibly plays a role in the contractile to secretory phenotypic transformation during atherosclerosis and vascular ageing, and in fibroblasts' migration and inflammatory responses in the adventitia. Physiologically, the LINC complex contributes to the stability of arteriolar structure, adaptations to changes in blood flow and injury repair mechanisms. Pathologically, dysregulation or mutations in LINC complex components can lead to compromised endothelial function, vascular remodelling and exacerbation of cardiovascular diseases such as atherosclerosis (arteriolosclerosis). This review summarizes our current understanding of the roles of the LINC complex in cells from arterioles, highlighting its most important physiological functions, exploring its implications for vascular pathology and emphasizing some of its functional characteristics in endothelial cells. By elucidating the LINC complex's role in health and disease, we aim to provide insights that could improve future therapeutic strategies targeting LINC complex-related vascular disorders. (Figure presented.).
dc.fuente.origenORCID
dc.identifier.doi10.1113/JP285906
dc.identifier.issn14697793 00223751
dc.identifier.scopusidSCOPUS_ID:85216616897
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/102764
dc.information.autorucEscuela de Medicina; Sobrevia Luarte, Luis Alberto; 0000-0001-5802-2243; 1002656
dc.language.isoes
dc.nota.accesoContenido parcial
dc.publisherJohn Wiley and Sons Inc
dc.revistaJournal of Physiology
dc.rightsacceso restringido
dc.subjectarterioles
dc.subjectendothelial cells
dc.subjectLINC complex
dc.subject.ddc570
dc.subject.deweyBiologíaes_ES
dc.titleThe LINC complex in blood vessels: from physiology to pathological implications in arterioles
dc.typeartículo
sipa.codpersvinculados1002656
sipa.trazabilidadORCID;2025-03-03
Files
Collections
Artículos de revistas