AGE-RELATED RESPONSES OF SKELETAL-MUSCLE AFTER ECTOPIC INNERVATION, WITH PARTICULAR REFERENCE TO 16S ACETYLCHOLINESTERASE, IN ADULT-RATS

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dc.contributor.authorMALDONADO, M
dc.contributor.authorRAMIREZ, BU
dc.contributor.authorRUIZ, G
dc.contributor.authorYAMUY, J
dc.contributor.authorINESTROSA, NC
dc.date.accessioned2025-01-23T19:43:50Z
dc.date.available2025-01-23T19:43:50Z
dc.date.issued1984
dc.description.abstractThe formation of ectopic junctions between the foreign fibular nerve and the soleus muscle of young (35-day-old) and mature (200-day-old) adult rats was induced by severing the normal nerve 4 wk after implanting the foreign nerve. The various molecular forms of acetylcholinesterase (AChE) were studied both at the implanted region and at the original denervated endplates. The velocity of contraction was also studied. In young rats the 16S form was first detected in the ectopic junctions around day 5 after reinnervation; this form rapidly increased during the following weeks, reaching a plateau by day 20. By contrast, in mature rats the appearance of the 16S AChE was dramatically delayed; in fact, it could not be observed before day 80 after reinnervation. (The 16S AChE form appeared at day 20 after reinnervation in the original denervated endplates of young rats; however, at the same time, no effect was observed in mature animals.) The original, slow muscle fibers of the soleus became faster upon reinnervation; this change also occurred much earlier in younger than in mature rats. A loss of plasticity in the skeletal muscle of mature rats is indicated. Caution is suggested in the use of the ectopic innervation model to study development in mature adult rats.
dc.fuente.origenWOS
dc.identifier.eissn1471-4159
dc.identifier.issn0022-3042
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99836
dc.identifier.wosidWOS:A1984SY95000012
dc.issue.numero2
dc.language.isoen
dc.pagina.final381
dc.pagina.inicio375
dc.revistaJournal of neurochemistry
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAGE-RELATED RESPONSES OF SKELETAL-MUSCLE AFTER ECTOPIC INNERVATION, WITH PARTICULAR REFERENCE TO 16S ACETYLCHOLINESTERASE, IN ADULT-RATS
dc.typeartículo
dc.volumen43
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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