Laminin blocks the assembly of wild type Aβ and the Dutch variant peptide into Alzheimer's fibrils

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dc.contributor.authorBronfman, FC
dc.contributor.authorAlvarez, A
dc.contributor.authorMorgan, C
dc.contributor.authorInestrosa, NC
dc.date.accessioned2025-01-21T01:32:47Z
dc.date.available2025-01-21T01:32:47Z
dc.date.issued1998
dc.description.abstractAmyloid fibril formation is believed to be a nucleation-dependent polymerization process which may be influenced by various other factors with important consequences for the development, prevention or treatment of amyloidosis. We have previously shown that laminin inhibits A beta peptide fibril formation in vitro. Here we present a kinetic study that indicates laminin to be a potent anti-amyloidosis factor, as it not only inhibited alpha beta(1-40) fibril aggregation, but also inhibited the aggregation of the Dutch A beta(1-40) variant, a peptide with a higher capacity to aggregate than the wild-type A beta(1-40). The inhibitory effect of laminin on amyloid fibril formation was not overcome by the addition of pre-formed A beta fibrils, suggesting that laminin inhibits the fibril elongation process. At the present time, however, we cannot rule out the possibility that laminin also affects the initial nucleation process of A beta fibril formation. On other hand, laminin was not able to counteract the amyloid fibril formation promoted by acetylcholinesterase (AChE), another component of the amyloid deposits found in AD brains. The effect of laminin may bet important as an inhibitor of A beta amyloidogenesis in vivo, specifically at the level of cerebral blood vessels.
dc.fuente.origenWOS
dc.identifier.eissn1744-2818
dc.identifier.issn1350-6129
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97321
dc.identifier.wosidWOS:000072518800003
dc.issue.numero1
dc.language.isoen
dc.pagina.final23
dc.pagina.inicio16
dc.revistaAmyloid-journal of protein folding disorders
dc.rightsacceso restringido
dc.subjectA beta protein
dc.subjectAlzheimer's disease
dc.subjectamyloid fibrils
dc.subjectDutch hereditary cerebral hemorrhage with amyloidosis
dc.subjectlaminin
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleLaminin blocks the assembly of wild type Aβ and the Dutch variant peptide into Alzheimer's fibrils
dc.typeartículo
dc.volumen5
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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