Thyme essential oil loaded microspheres for fish fungal infection: microstructure, <i>in vitro</i> dynamic release and antifungal activity

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dc.contributor.authorBenavides, Sergio
dc.contributor.authorMariotti-Celis, Maria Salome
dc.contributor.authorParedes, Maria Jose Carolina
dc.contributor.authorParada, Javier A.
dc.contributor.authorFranco, Wendy V.
dc.date.accessioned2025-01-20T23:56:02Z
dc.date.available2025-01-20T23:56:02Z
dc.date.issued2021
dc.description.abstractAims
dc.description.abstractEvaluate the effect of varying the droplet size of microspheres charged with thyme essential oil (TEO-MS) on their swelling (Sw), release rate (%RR) and in vitro antifungal activity against Saprolegnia sp.
dc.description.abstractMethods
dc.description.abstractTEO-MS obtained by ionic gelation were characterised through SEM microscopy and X-ray microtomography. Their Sw and RR% were evaluated at simulated fish-gastrointestinal conditions using gravimetric and spectrophotometric techniques.
dc.description.abstractResults
dc.description.abstractFor all evaluated droplet sizes (p >= 0.05), TEO was heterogeneously distributed inside of the MS and TEO-MS experimented agglomeration and sphericity loss after the drying process. Under gastric conditions, the acid pH (2.9) limited the Sw (50-100%) of TEO-MS, generating a low RR% (14-18%). Contrary, the slightly alkaline intestinal pH (8.1) favoured the Sw (similar to 3.2 to 3.8 times) and therefore the RR% (42-63%).
dc.description.abstractConclusions
dc.description.abstractTEO-MS (5-100 mg/mL) presented antifungal capacity onto Saprolegnia sp. after the simulated fish digestion, being the small droplet size once the most effective.
dc.fuente.origenWOS
dc.identifier.doi10.1080/02652048.2020.1836055
dc.identifier.eissn1464-5246
dc.identifier.issn0265-2048
dc.identifier.urihttps://doi.org/10.1080/02652048.2020.1836055
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95128
dc.identifier.wosidWOS:000583922600001
dc.issue.numero1
dc.language.isoen
dc.pagina.final21
dc.pagina.inicio11
dc.revistaJournal of microencapsulation
dc.rightsacceso restringido
dc.subjectMicrospheres
dc.subjectessential oil
dc.subjectmicrostructure
dc.subjectantifungal capacity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleThyme essential oil loaded microspheres for fish fungal infection: microstructure, <i>in vitro</i> dynamic release and antifungal activity
dc.typeartículo
dc.volumen38
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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