The Nath-Luxuriæ principles: Unified thermodynamic framework for molecular assembly and non-ergodicity via ATP synthesis/hydrolysis example

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dc.article.number105481
dc.catalogadorgjm
dc.contributor.authorVenegas Aravena, Patricio
dc.contributor.authorCordaro, Enrique G.
dc.date.accessioned2025-06-04T15:47:46Z
dc.date.available2025-06-04T15:47:46Z
dc.date.issued2025
dc.description.abstractNath's principle posits that the maximization of free energy dissipation () under specific constraints facilitates the function and assembly of complex organic molecules under specific constraints, challenging the classical view that increased dissipation leads to disorder. To ground this principle in thermodynamics, this study establishes a connection between Nath's principle and a principle applicable beyond biological systems: the Principium Luxuriæ. The latter describes how multiscale systems dissipate energy in response to external forces. The conceptual equivalence of both principles is demonstrated, supporting Nath's unified theory of ATP synthesis/hydrolysis and the existence of non-equilibrium mechanisms for cellular energy dissipation, conservation, and storage. This connection is reinforced by a mathematical relationship demonstrating a negative correlation between and the thermodynamic fractal dimension (), a parameter quantifying multiscale dissipation in the Principium Luxuriæ. Furthermore, a relationship is established between the equations governing homeostasis and free energy. Given that the multiscale description is predicated on constraints imposed by external forces, which limit possible molecular configurations, the non-ergodic nature of biological systems described by Nath's principle is validated. A comparative analysis is conducted, contrasting these Nath-Luxuriæ principles with Prigogine's work (which describes ergodic systems) in their application to the thermodynamic evolution of biological systems and the constraints present on Earth for the formation of life. It is suggested that the Nath-Luxuriæ principles may significantly enhance the probability of assembling complex molecules necessary for life.
dc.format.extent11 páginas
dc.fuente.origenORCID
dc.identifier.doi10.1016/j.biosystems.2025.105481
dc.identifier.urihttps://doi.org/10.1016/j.biosystems.2025.105481
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/104576
dc.information.autorucEscuela de Ingeniería; Venegas Aravena, Patricio; S/I; 1080976
dc.language.isoen
dc.nota.accesocontenido parcial
dc.revistaBioSystems
dc.rightsacceso restringido
dc.subjectATP synthesis
dc.subjectMultiscale thermodynamics
dc.subjectBiological complexity
dc.subjectNon-equilibrium thermodynamics
dc.subjectHomeostasis
dc.subjectThermodynamic fractal dimension
dc.subjectEmergent behavior
dc.subjectDissipative structures
dc.subjectConservative structures
dc.subjectNath’s torsional mechanism and unified theory of ATP synthesis/hydrolysis
dc.subjectFourth law/principle of thermodynamics
dc.subjectConstrained optimization
dc.subject.ddc600
dc.subject.deweyTecnologíaes_ES
dc.titleThe Nath-Luxuriæ principles: Unified thermodynamic framework for molecular assembly and non-ergodicity via ATP synthesis/hydrolysis example
dc.typeartículo
dc.volumen253
sipa.codpersvinculados1080976
sipa.trazabilidadORCID;2025-06-03
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