Accidental clozapine intoxication in a ten-year-old child

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dc.contributor.authorBorzutzky, A
dc.contributor.authorAvello, E
dc.contributor.authorRumie, H
dc.contributor.authorParis, E
dc.date.accessioned2025-01-21T01:08:39Z
dc.date.available2025-01-21T01:08:39Z
dc.date.issued2003
dc.description.abstractClozapine is a tricyclic dibenzodiazepine derivative used commonly in the treatment of schizophrenia. Severe side effects of overdose have been described in children. This report describes the unintentional ingestion of clozapine by a 10-y-o girl, presenting dramatic changes of mental status and progressive alteration of consciousness with a Glasgow Coma Scale drop from 12 to 7. Urine analysis revealed 500 mug clozapine/L 24 h after ingestion. Full resolution of symptoms occurred after approximated 55 h with no sequels or alterations at follow-up. Awareness must be taken when administering atypical antipsychotics such as clozapine to children because of the severe intoxication effects cases reported.
dc.fuente.origenWOS
dc.identifier.issn0145-6296
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96494
dc.identifier.wosidWOS:000186648900006
dc.issue.numero6
dc.language.isoen
dc.pagina.final310
dc.pagina.inicio309
dc.revistaVeterinary and human toxicology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleAccidental clozapine intoxication in a ten-year-old child
dc.typeartículo
dc.volumen45
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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