ACTIVATION OF HYPOLIPEMIC DRUGS TO ACYL-COENZYME-A THIOESTERS

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dc.contributor.authorBRONFMAN, M
dc.contributor.authorAMIGO, L
dc.contributor.authorMORALES, MN
dc.date.accessioned2025-01-23T19:26:12Z
dc.date.available2025-01-23T19:26:12Z
dc.date.issued1986
dc.description.abstractCompounds possessing the characteristics of CoA thioesters of the hypolipidaemic peroxisome proliferators clofibric acid, nafenopin and ciprofibrate were formed on incubation of the drugs with rat liver microsomal fractions, ATP and CoA. The reactivity of the drugs correlated with their pharmacological potency. It is proposed that the active species of these compounds are their acyl-CoA thioesters.
dc.fuente.origenWOS
dc.identifier.eissn1470-8728
dc.identifier.issn0264-6021
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99579
dc.identifier.wosidWOS:A1986E714700043
dc.issue.numero3
dc.language.isoen
dc.pagina.final784
dc.pagina.inicio781
dc.revistaBiochemical journal
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleACTIVATION OF HYPOLIPEMIC DRUGS TO ACYL-COENZYME-A THIOESTERS
dc.typeartículo
dc.volumen239
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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