Effects of Sleeve Gastrectomy and Medical Treatment for Obesity on Glucagon-like Peptide 1 Levels and Glucose Homeostasis in Non-diabetic Subjects

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dc.contributor.authorPatricio Valderas, Juan
dc.contributor.authorIrribarra, Veronica
dc.contributor.authorRubio, Lorena
dc.contributor.authorBoza, Camilo
dc.contributor.authorEscalona, Manuel
dc.contributor.authorLiberona, Yessica
dc.contributor.authorMatamala, Andrea
dc.contributor.authorMaiz, Alberto
dc.date.accessioned2025-01-21T00:01:40Z
dc.date.available2025-01-21T00:01:40Z
dc.date.issued2011
dc.description.abstractThe effects of medical and surgical treatments for obesity on glucose metabolism and glucagon-like peptide 1 (GLP-1) levels independent of weight loss remain unclear. This study aims to assess plasma glucose levels, insulin sensitivity and secretion, and GLP-1 levels before and after sleeve gastrectomy (SG) or medical treatment (MED) for obesity.
dc.description.abstractThis study is a prospective, controlled, non-randomised study. Two groups of non-diabetic obese patients with similar BMIs, including a SG group (BMI, 35.5 +/- 0.9 kg/m(2); n = 6) and a MED group (BMI, 37.7 +/- 1.9 kg/m(2); n = 6) and a group of lean subjects (BMI, 21.7 +/- 0.7 kg/m(2); n = 8).
dc.description.abstractPlasma glucose, insulin, and total GLP-1 levels at fasting and after the intake of a standard liquid meal at baseline and at 2 months post-intervention. At baseline, total GLP-1 levels were similar, but obese patients had lower insulin sensitivity and higher insulin secretion than lean subjects. At 2 months post-intervention, SG and MED patients achieved similar weight loss (14.4 +/- 0.8%, 15.3 +/- 0.9%, respectively). Insulin sensitivity increased in SG and MED patients; however, postprandial insulin secretion decreased after MED, but not after SG. The incremental area under the curve of GLP-1 increased after SG (P = 0.04), but not after MED.
dc.description.abstractWeight loss by medical or surgical treatment improved insulin sensitivity. However, only MED corrected the hyperinsulinemic postprandial state associated to obesity. Postprandial GLP-1 levels increased significantly after SG without duodenal exclusion, which may explain why insulin secretion did not decrease following this surgery.
dc.fuente.origenWOS
dc.identifier.doi10.1007/s11695-011-0375-4
dc.identifier.eissn1708-0428
dc.identifier.issn0960-8923
dc.identifier.urihttps://doi.org/10.1007/s11695-011-0375-4
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/95390
dc.identifier.wosidWOS:000291981700014
dc.issue.numero7
dc.language.isoen
dc.pagina.final909
dc.pagina.inicio902
dc.revistaObesity surgery
dc.rightsacceso restringido
dc.subjectGlucagon-like peptide 1
dc.subjectSleeve gastrectomy
dc.subjectDiet
dc.subjectInsulin-resistance
dc.subjectObesity
dc.subjectWeight loss
dc.subjectInsulin secretion
dc.subjectSurgery for obesity
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEffects of Sleeve Gastrectomy and Medical Treatment for Obesity on Glucagon-like Peptide 1 Levels and Glucose Homeostasis in Non-diabetic Subjects
dc.typeartículo
dc.volumen21
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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