Juice and phenolic fractions of the berry <i>Aristotelia chilensis</i> inhibit LDL oxidation <i>in vitro</i> and protect human endothelial cells against oxidative stress

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dc.contributor.authorMiranda-Rottmann, S
dc.contributor.authorAspillaga, AA
dc.contributor.authorPérez, DD
dc.contributor.authorVasquez, L
dc.contributor.authorMartinez, ALF
dc.contributor.authorLeighton, F
dc.date.accessioned2025-01-21T01:10:07Z
dc.date.available2025-01-21T01:10:07Z
dc.date.issued2002
dc.description.abstractOxidative modification of low-density lipoprotein (LDL) particles is a key event in the development of atherosclerosis. Oxidized LDL induces oxidative stress and modifies gene expression in endothelial cells. Berries constitute a rich dietary source of phenolic antioxidants. We found that the endemic Chilean berry Aristotelia chilensis (ach) has higher phenol content and scores better for total radical-trapping potential and total antioxidant reactivity in in vitro antioxidant capacity tests, when compared to different commercial berries. The juice of ach is also effective in inhibiting copper-induced LDL oxidation. In human endothelial cell cultures, the addition of ach juice significantly protects from hydrogen peroxide-induced intracellular oxidative stress and is dose-dependent. The aqueous, anthocyanin-rich fraction of ach juice accounts for most of ach's antioxidant properties. These results show that ach is a rich source of phenolics with high antioxidant capacity and suggest that it may have antiatherogenic properties.
dc.fuente.origenWOS
dc.identifier.doi10.1021/jf025797n
dc.identifier.eissn1520-5118
dc.identifier.issn0021-8561
dc.identifier.urihttps://doi.org/10.1021/jf025797n
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/96653
dc.identifier.wosidWOS:000179833700009
dc.issue.numero26
dc.language.isoen
dc.pagina.final7547
dc.pagina.inicio7542
dc.revistaJournal of agricultural and food chemistry
dc.rightsacceso restringido
dc.subjectoxidative stress
dc.subjectphenolic antioxidants
dc.subjectLDL oxidation
dc.subjectendothelial cell
dc.subjectAristotelia chilensis
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleJuice and phenolic fractions of the berry <i>Aristotelia chilensis</i> inhibit LDL oxidation <i>in vitro</i> and protect human endothelial cells against oxidative stress
dc.typeartículo
dc.volumen50
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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