EFFECT OF BEAN INTAKE ON BILIARY LIPID SECRETION AND ON HEPATIC CHOLESTEROL-METABOLISM IN THE RAT

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dc.contributor.authorRIGOTTI, A
dc.contributor.authorMARZOLO, MP
dc.contributor.authorULLOA, N
dc.contributor.authorGONZALEZ, O
dc.contributor.authorNERVI, F
dc.date.accessioned2025-01-23T19:23:49Z
dc.date.available2025-01-23T19:23:49Z
dc.date.issued1989
dc.description.abstractWe studied the effect of a bean diet on biliary lipid secretion, serum cholesterol concentration, and hepatic cholesterol metabolism in the rat. Rats fed a bean diet for 10-12 days had increased biliary cholesterol output and molar percentage by 300% and 200%, respectively, compared to rats fed an isocaloric and isoproteinic casein diet. Biliary phospholipid output increased 180%. Bile flow and biliary salt output remained in the normal range. Total serum and VLDL cholesterol concentration significantly decreased 27% and 50%, respectively, in the rats fed the bean diet. Hepatic cholesterogenesis was increased 170% in the bean-fed animals. The relative contribution of newly synthesized hepatic cholesterol to total biliary cholesterol increased 200%, and that of endogenous origin only 50%. These results suggested that newly synthetized hepatic cholesterol was preferentially channelled to the biliary cholesterol pathway in bean-fed rats. Although hepatic cholesteryl ester concentration increased 240%, the incorporation of [14C]oleate into hepatic cholesteryl esters was significantly decreased by 30% in isolated hepatocytes of bean-fed animals. These results were consistent with the possibility that the availability of hepatic free cholesterol for biliary secretion was increased in the bean-fed animals. This study demonstrates that bean intake has a profound effect on the metabolic channelling and compartmentalization of hepatic cholesterol, resulting in a significant decrease in total serum and very low density lipoprotein cholesterol concentrations and a high biliary cholesterol output.
dc.fuente.origenWOS
dc.identifier.eissn1539-7262
dc.identifier.issn0022-2275
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99270
dc.identifier.wosidWOS:A1989AG42000011
dc.issue.numero7
dc.language.isoen
dc.pagina.final1048
dc.pagina.inicio1041
dc.revistaJournal of lipid research
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleEFFECT OF BEAN INTAKE ON BILIARY LIPID SECRETION AND ON HEPATIC CHOLESTEROL-METABOLISM IN THE RAT
dc.typeartículo
dc.volumen30
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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