CAROTID-BODY CHEMORECEPTOR EXCITATION PRODUCED BY CAROTID OCCLUSION

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dc.contributor.authorALCAYAGA, J
dc.contributor.authorITURRIAGA, R
dc.contributor.authorZAPATA, P
dc.date.accessioned2025-01-23T19:26:43Z
dc.date.available2025-01-23T19:26:43Z
dc.date.issued1986
dc.description.abstractThe effects of common carotid artery occlusions on the afferent activity recorded from the carotid (sinus) nerve were studied in 20 pentobarbitone anesthetized cats. Ipsilateral occlusions lowered intrasinusal pressure down to 15-100 torr, depending on previous pressures, and resulted in silencing of carotid barosensory impulses. For cats breathing room air and with mean systemic arterial pressure below 125 torr, chemosensory excitation was induced whenever these occlusions lasted 5 sec or longer and it persisted during 10 min occlusions. The chemosensory excitation had a delay of about 4 sec and the maximal frequency of discharges was attained at nearly 30 sec, followed by a maintained submaximal level of about 80-90% of the peak frequency. For ipsilateral occlusions performed under 100% O2 inhalation, the delay of the excitation was increased to ca. 20 sec and the maximal frequency attained only 30-40% of that obtained for the same animal when breathing room air. Bilateral occlusions caused deeper falls in intrasinusal pressure and stronger chemoreceptor excitation. When arterial pressure was above 130 torr, ipsilateral occlusions only produced transient increases in chemosensory discharges or suppression of their ventilatory fluctuations. Chemical stimuli further increased chemosensory frequency during occlusions, indicating that blood flow through carotid body was not arrested. It is concluded that occlusions of the common carotid may induce an increased frequency of carotid chemosensory discharges. This increment is dependent on systemic arterial pressure, ventilatory conditions and duration of the occlusion. It is suggested that the increased carotid chemosensory activity may interact with the withdrawal of barosensory discharges to elicit the reflex changes observed during carotid occlusions.
dc.fuente.origenWOS
dc.identifier.issn0001-6764
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99646
dc.identifier.wosidWOS:A1986D769500001
dc.issue.numero3
dc.language.isoen
dc.pagina.final215
dc.pagina.inicio199
dc.revistaActa physiologica et pharmacologica latinoamericana
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleCAROTID-BODY CHEMORECEPTOR EXCITATION PRODUCED BY CAROTID OCCLUSION
dc.typeartículo
dc.volumen36
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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