CHANGES IN SERUM LEVELS OF SHBG, ENDOGENOUS LIGANDS AND LEVONORGESTREL INDUCED BY ETHINYLESTRADIOL IN NORPLANT USERS

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dc.contributor.authorNOE, G
dc.contributor.authorPAVEZ, M
dc.contributor.authorCROXATTO, HB
dc.date.accessioned2025-01-23T19:22:16Z
dc.date.available2025-01-23T19:22:16Z
dc.date.issued1992
dc.description.abstractThis work was done in search for a model to examine target organ response to fluctuations in serum levels of sex hormone-binding globulin (SHBG) and its ligands. The time course and magnitude of fluctuations of SHBG, levonorgestrel (L-Ng), estradiol (E2), testosterone (T) and dihydrotestosterone (DHT) in serum were examined during and after treatment with 50 ug of ethinylestradiol (EE2) daily for 10 days in 10 volunteer women using NORPLANT(R) implants. Six of these volunteers were also treated with 20 ug of EE2 daily for 7 days and two additional volunteers using a copper-T IUD were treated with 50 ug of EE2 daily for 7 days. In all cases, SHBG and L-Ng levels increased in a close parallel manner several-fold above basal levels during treatment, reaching a maximum around two days after the last EE2 pill. In contrast, the levels of E2 and T increased in one subject, decreased in 5 and remained unchanged in 4, while changes of DHT were unrelated to those of the other ligands.
dc.description.abstractSince the L-Ng "secretion rate" by NORPLANT(R) implants is constant, it follows that the effect of EE2 on its levels is due to a decreased metabolic clearance rate, most likely secondary to the increased binding of L-Ng to SHBG in serum. This interpretation is in agreement with the close parallelism in the fluctuations of L-Ng and SHBG.
dc.description.abstractIt is concluded that in NORPLANT(R) users, SHBG and L-Ng, but not the endogenous ligands, behave in a predictable manner in response to EE2. Thus, this model affords the possibility of exploring the influence of SHBG on tissue response to progestins.
dc.fuente.origenWOS
dc.identifier.issn0010-7824
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/99005
dc.identifier.wosidWOS:A1992HJ81000001
dc.issue.numero3
dc.language.isoen
dc.pagina.final201
dc.pagina.inicio187
dc.revistaContraception
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.ods05 Gender Equality
dc.subject.odspa03 Salud y bienestar
dc.subject.odspa05 Igualdad de género
dc.titleCHANGES IN SERUM LEVELS OF SHBG, ENDOGENOUS LIGANDS AND LEVONORGESTREL INDUCED BY ETHINYLESTRADIOL IN NORPLANT USERS
dc.typeartículo
dc.volumen45
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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