MITOSIS OF SCHWANN-CELLS AND DEMYELINATION ARE INDUCED BY THE AMYLOID PRECURSOR PROTEIN AND OTHER PROTEASE INHIBITORS IN THE RAT SCIATIC-NERVE

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dc.contributor.authorALVAREZ, J
dc.contributor.authorMORENO, RD
dc.contributor.authorINESTROSA, NC
dc.date.accessioned2025-01-21T01:35:06Z
dc.date.available2025-01-21T01:35:06Z
dc.date.issued1995
dc.description.abstractWe studied the cytological alterations produced in the rat sciatic nerve by the amyloid precursor protein (APP) containing the Kunitz insert (APP K+) and other protease inhibitors. Conditioning of nerve segments with APP K+, aprotinin or leupeptin for 5 days or more resulted in mitosis of Schwann cells, demyelination of fibres, and a <10-fold increase in Schwann cells, associated with demyelinated fibres. Altered fibres nevertheless involved a small part of the population. Nerve segments proximal and distal to the conditioned region showed almost no alteration. Conditioning with saline, heated APP K+, or APP without the Kunitz insert was not effective. We conclude that APP K+ and other protease inhibitors induce Schwann cells to enter the cell cycle, and once committed to proliferate they resorb their myelin. These functional properties of APP may be relevant to the pathogenesis of Alzheimer's disease.
dc.fuente.origenWOS
dc.identifier.issn0953-816X
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/97641
dc.identifier.wosidWOS:A1995QH60800016
dc.issue.numero1
dc.language.isoen
dc.pagina.final159
dc.pagina.inicio152
dc.revistaEuropean journal of neuroscience
dc.rightsacceso restringido
dc.subjectALZHEIMER
dc.subjectCELL CYCLE
dc.subjectPROLIFERATION
dc.subjectKUNITZ
dc.subjectAPP
dc.subjectSERPIN
dc.subjectLEUPEPTIN
dc.subjectAPROTININ
dc.subjectMYELIN
dc.subjectSCIATIC NERVE
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleMITOSIS OF SCHWANN-CELLS AND DEMYELINATION ARE INDUCED BY THE AMYLOID PRECURSOR PROTEIN AND OTHER PROTEASE INHIBITORS IN THE RAT SCIATIC-NERVE
dc.typeartículo
dc.volumen7
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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