Regional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression

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dc.contributor.authorButte, Jean M.
dc.contributor.authorTorres, Javiera
dc.contributor.authorVeras, Emanuela F.
dc.contributor.authorMatsuo, Kenichi
dc.contributor.authorGoenen, Mithat
dc.contributor.authorD'Angelica, Michael I.
dc.contributor.authorWaugh, Enrique
dc.contributor.authorMeneses, Manuel
dc.contributor.authorInayama, Yoshiyaki
dc.contributor.authorFong, Yuman
dc.contributor.authorDeMatteo, Ronald P.
dc.contributor.authorDe La Fuente, Hernan
dc.contributor.authorEndo, Itaru
dc.contributor.authorKlimstra, David S.
dc.contributor.authorJarnagin, William R.
dc.date.accessioned2025-01-24T00:04:11Z
dc.date.available2025-01-24T00:04:11Z
dc.date.issued2013
dc.description.abstractThe variable incidence of gallbladder cancer (GBCA) suggests regional pathogenetic differences. This study compares cell cycle-regulatory, angiogenesis-related, and PI3K pathway protein expression in GBCAs from three continents.
dc.description.abstractImmunohistochemical expression of several proteins was assessed, correlated with clinicopathologic variables, and compared among centers from Chile (Fundacin Arturo Lpez P,rez [FALP]), Japan (Yokohama City University [YCU]), and the United States (Memorial Sloan-Kettering Cancer Center [MSKCC]). Hierarchical clustering was used to partition the data based on protein-expression and treatment center.
dc.description.abstractTissue from 117 patients (MSKCC = 76; FALP = 22; YCU = 19) was analyzed. Mdm2 overexpression was seen only at MSKCC (p < 0.0001). Absence of p21 (p = 0.03) and VEGFR2 (p = 0.018) were more common and p27 expression was less frequent (p = 0.047) in tumors from YCU. Ki-67 labeling index in YCU tumors (median = 10) was two-thirds lower than at other centers. On hierarchical clustering analysis, all YCU patients (p = 0.017) and those with early tumors (p = 0.017) clustered separately from MSKCC. Median disease-specific survival after curative intent (R0) resection was 27 months and was similar among centers (p = 0.9). Median disease-specific survival of patients with early tumors was 28.4 months and was higher at YCU (not reached, p = 0.06).
dc.description.abstractCell cycle-regulatory protein expression patterns of YCU tumors differed from those treated at FALP and MSKCC. The differential clustering of protein expression and survival in patients with early tumors suggest regional differences in pathogenesis and disease biology.
dc.description.funderNCI NIH HHS
dc.fuente.origenWOS
dc.identifier.doi10.1245/s10434-012-2761-0
dc.identifier.eissn1534-4681
dc.identifier.issn1068-9265
dc.identifier.urihttps://doi.org/10.1245/s10434-012-2761-0
dc.identifier.urihttps://repositorio.uc.cl/handle/11534/101790
dc.identifier.wosidWOS:000317308200011
dc.issue.numero5
dc.language.isoen
dc.pagina.final1481
dc.pagina.inicio1470
dc.revistaAnnals of surgical oncology
dc.rightsacceso restringido
dc.subject.ods03 Good Health and Well-being
dc.subject.odspa03 Salud y bienestar
dc.titleRegional Differences in Gallbladder Cancer Pathogenesis: Insights from a Comparison of Cell Cycle-Regulatory, PI3K, and Pro-Angiogenic Protein Expression
dc.typeartículo
dc.volumen20
sipa.indexWOS
sipa.trazabilidadWOS;2025-01-12
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